Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | WDR5 | P61964 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166360 | 0.89 | CTSA (0.33) | CTSANPC1RAB9ASMN1; SMN2CYP11B2 | |
| SCHEMBL18166369 | 0.87 | P2RX3 (0.38) | CTSANPC1RAB9AMAPTWDR5 | |
| SCHEMBL18166423 | 0.86 | P2RX3 (0.40) | TP53PRCPIDH1WDR5 | |
| SCHEMBL18166458 | 0.86 | P2RX3 (0.34) | CTSANPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL18166418 | 0.84 | P2RX3 (0.39) | CTSAMAPK1IDH1NPC1RAB9A | |
| SCHEMBL18036347 | 0.84 | TP53 (0.43) | TP53PRCPSMN1; SMN2MAPTWDR5 | |
| SCHEMBL18036313 | 0.84 | TP53 (0.43) | TP53PRCPSMN1; SMN2MAPTWDR5 | |
| SCHEMBL18166457 | 0.78 | P2RX3 (0.42) | TP53PRCP | |
| SCHEMBL10244222 | 0.78 | NAMPT (0.45) | TP53PRCPMAPK1IDO1WDR5 | |
| SCHEMBL10243831 | 0.77 | P2RX3 (0.40) | CYP11B2WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038264-B1 | TETRAZOLE-SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2016-10-26 | — | — | EP | claimed |