Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 6/20 | 0.72 |
| ▸ | ACHE | P22303 | 6/20 | 0.72 |
| ▸ | BACE1 | P56817 | 6/20 | 0.72 |
| ▸ | DRD2 | P14416 | 1/20 | 0.64 |
| ▸ | DRD4 | P21917 | 1/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.58 |
| ▸ | CCR2 | P41597 | 1/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.55 |
| ▸ | FAAH | O00519 | 1/20 | 0.55 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.55 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.54 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.54 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.54 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.54 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.54 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.54 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL331018 | 0.86 | BCHE (0.68) | BCHEACHEBACE1DRD2DRD4 | |
| SCHEMBL331017 | 0.86 | BCHE (0.68) | BCHEACHEBACE1DRD2DRD4 | |
| SCHEMBL660073 | 0.83 | ROCK2 (0.62) | BCHEACHEBACE1SIGMAR1ROCK2 | |
| SCHEMBL2275025 | 0.81 | ROCK2 (0.61) | BCHEACHEBACE1SIGMAR1ROCK2 | |
| SCHEMBL24126796 | 0.79 | BCHE (0.63) | BCHEACHEBACE1DRD2DRD4 | |
| SCHEMBL5870954 | 0.78 | ROCK2 (0.65) | BCHEACHEBACE1ROCK2CCR2 | |
| SCHEMBL7214418 | 0.78 | ACHE (1.00) | BCHEACHEBACE1SIGMAR1 | |
| SCHEMBL8712569 | 0.78 | DRD4 (1.00) | DRD2DRD4 | |
| SCHEMBL6156841 | 0.78 | GAA (0.59) | BCHEACHEBACE1DRD2DRD4 | |
| SCHEMBL918426 | 0.77 | KDM4E (0.66) | BCHEACHEBACE1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035371-B1 | SUBSTITUTED PHENYL METHANONE DERIVATIVES AND THEIR USE AS GLYT1 AND GLYT2 RECEPTOR INHIBITORS | HOFFMANN LA ROCHE (CH) | 2013-03-06 | — | — | EP | disclosed |
| US-7951836-B2 | Substituted phenyl methanone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |
| EP-2035371-A2 | SUBSTITUTED PHENYL METHANONE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-18 | — | — | EP | disclosed |
| US-20070299071-A1 | Substituted phenyl methanone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-12-27 | — | — | US | disclosed |
| WO-2007147770-A2 | SUBSTITUTED PHENYL METHANONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299071-A1 | Substituted phenyl methanone derivatives | CYP11B1, CYP11B2, MC2R | BCHE 1717/4885ACHE 638/4885BACE1 674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.