SCHEMBL18174729

SCHEMBL18174729

Cc1cnccc1-c1ccc(-c2c3ccccc3c(-c3cccc(-c4ccccn4)c3)c3ccccc23)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.42
HRH3 Q9Y5N1 1/20 0.38
GRM4 Q14833 1/20 0.37
CYP17A1 P05093 1/20 0.37
CYP1A2 P05177 1/20 0.37
GRM5 P41594 2/20 0.37
TGFBR1 P36897 1/20 0.37
IRAK4 Q9NWZ3 1/20 0.37
KDR P35968 1/20 0.36
CYP19A1 P11511 1/20 0.36
DHODH Q02127 1/20 0.36
S1PR1 P21453 2/20 0.36
S1PR3 Q99500 1/20 0.36
CCNC P24863 1/20 0.36
CDK8 P49336 1/20 0.36
MAPK14 Q16539 1/20 0.36
BRD4 O60885 1/20 0.35
DCTPP1 Q9H773 1/20 0.35
DYRK1A Q13627 1/20 0.35
DYRK1B Q9Y463 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18174719 0.90 DHODH (0.46) CYP2A6HRH3CYP17A1CYP1A2TGFBR1
SCHEMBL18174633 0.89 CYP2A6 (0.38) CYP2A6GRM4CYP17A1DHODHS1PR1
SCHEMBL18174750 0.88 GRM4 (0.43) GRM4CYP17A1CYP1A2CYP19A1DHODH
SCHEMBL18174752 0.88 CYP3A4 (0.47) CYP2A6GRM4CYP17A1CYP1A2CYP19A1
SCHEMBL18174732 0.88 CYP2A6 (0.49) CYP2A6GRM4CYP17A1CYP1A2TGFBR1
SCHEMBL18174663 0.88 GRM4 (0.37) CYP2A6GRM4CYP17A1TGFBR1CYP19A1
SCHEMBL18174736 0.87 CYP2A6 (0.48) CYP2A6GRM4CYP17A1CYP1A2TGFBR1
SCHEMBL18174753 0.85 PIK3CA (0.45) GRM4CYP17A1CYP1A2CYP19A1DHODH
SCHEMBL18174725 0.84 CYP2A6 (0.49) CYP2A6GRM4CYP17A1CYP1A2CYP19A1
SCHEMBL18174755 0.84 DHODH (0.41) GRM4CYP17A1CYP1A2CYP19A1DHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9478750-B2 Anthracene derivative and organic electroluminescent element using the same JNC CORPORATION (JP) 2016-10-25 US disclosed
US-9478750-B2 Anthracene derivative and organic electroluminescent element using the same JNC CORPORATION (JP) 2016-10-25 US disclosed