Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD4 | Q15561 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | FECH | P22830 | 1/20 | 0.37 |
| ▸ | MYH14 | Q7Z406 | 1/20 | 0.37 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12872519 | 0.84 | ALDH1A1 (0.44) | TEAD4ERBB2EGFRNQO2FECH | |
| SCHEMBL18177582 | 0.84 | ALDH1A1 (0.42) | PIK3CDERBB2EGFRNQO2FECH | |
| SCHEMBL20172422 | 0.80 | ERBB2 (0.40) | ERBB2EGFRNQO2FECHMYH14 | |
| SCHEMBL26005853 | 0.79 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2APOLBMAPT | |
| SCHEMBL21563376 | 0.78 | PIK3CD (0.47) | PIK3CDERBB2EGFRALDH1A1EGLN2 | |
| SCHEMBL25177224 | 0.77 | NR4A1 (0.36) | PIK3CDERBB2EGFRNQO2FECH | |
| SCHEMBL26894024 | 0.77 | ERBB2 (0.43) | PIK3CDERBB2EGFRNQO2FECH | |
| SCHEMBL260059 | 0.76 | DNMT1 (0.39) | PIK3CDEGFRALDH1A1SMN1; SMN2EGLN2 | |
| SCHEMBL26579583 | 0.76 | ERBB2 (0.44) | PIK3CDERBB2EGFRNQO2FECH | |
| SCHEMBL25572680 | 0.75 | ERBB2 (0.44) | ERBB2EGFRNQO2FECHMYH14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160311780-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE AVILOMICS RES INC (US) | 2016-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160311780-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | ABCG2, CYP3A43, CYP3A5 | TEAD4 3129/4885PIK3CD 1571/4885ERBB2 918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.