Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.47 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.45 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 5/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 4/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30613048 | 0.85 | PIK3CD (0.40) | PIK3CDEGFRTGFBR1ERBB2PDE10A | |
| SCHEMBL18177582 | 0.75 | ALDH1A1 (0.42) | PIK3CDEGFRERBB2KDM4EALDH1A1 | |
| SCHEMBL29907348 | 0.75 | ERBB2 (0.46) | EGFRERBB2ALDH1A1 | |
| SCHEMBL23432223 | 0.75 | TGFBR1 (0.40) | PIK3CDTGFBR1PDE10A | |
| SCHEMBL260059 | 0.75 | DNMT1 (0.39) | PIK3CDEGLN2CCR1CCR5CCR8 | |
| SCHEMBL24167317 | 0.74 | MAOB (0.47) | EGLN2ALDH1A1 | |
| SCHEMBL15639111 | 0.74 | PIK3CD (0.45) | PIK3CDEGLN2TGFBR1KDM4EALDH1A1 | |
| SCHEMBL15639536 | 0.72 | MAPT (0.49) | PIK3CDEGLN2KITKDM4EALDH1A1 | |
| SCHEMBL20172422 | 0.72 | ERBB2 (0.40) | EGFRERBB2 | |
| SCHEMBL29414877 | 0.72 | ERBB2 (0.48) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044570-A1 | COMPOUNDS AND METHODS FOR MODULATING HER2 | IAMBIC THERAPEUTICS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |
| US-10822334-B2 | ErbB receptor inhibitors | DIZAL JIANGSU PHARMACEUTICAL CO LTD (CN) | 2020-11-03 | — | — | US | disclosed |
| US-20200317669-A1 | ERBB RECEPTOR INHIBITORS | DIZAL JIANGSU PHARMACEUTICAL CO LTD (CN) | 2020-10-08 | — | — | US | disclosed |
| WO-2019214634-A1 | ERBB RECEPTOR INHIBITORS | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2019-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10822334-B2 | ErbB receptor inhibitors | ERBB2, EGFR, ERBB3 | PIK3CD 75/4885EGLN2 2826/4885CCR1 2053/4885 |
| US-20200317669-A1 | ERBB RECEPTOR INHIBITORS | ERBB2, EGFR, ERBB3 | PIK3CD 75/4885EGLN2 2826/4885CCR1 2053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.