Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | ERN1 | O75460 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18188991 | 0.88 | ABCG2 (0.50) | ABCG2ERN1ALDH1A1SRCCA1 | |
| SCHEMBL11043755 | 0.85 | ALDH1A1 (0.45) | ABCG2ERN1ALDH1A1SRCNPC1 | |
| SCHEMBL31474876 | 0.84 | ALDH1A1 (0.56) | ABCG2ERN1ALDH1A1SRCCA1 | |
| SCHEMBL269268 | 0.84 | ALDH1A1 (0.56) | ABCG2ERN1ALDH1A1SRCCA1 | |
| SCHEMBL16048364 | 0.83 | SRC (0.60) | ERN1ALDH1A1SRCCA1CA2 | |
| Alcohol SCHEMBL28299718 | 0.79 | ABCG2 (0.51) | ABCG2ERN1ALDH1A1SRCCA1 | |
| SCHEMBL6901102 | 0.78 | ABCG2 (0.46) | ABCG2ERN1ALDH1A1CA1CA2 | |
| SCHEMBL2799192 | 0.78 | KMT2A (0.52) | ABCG2ERN1ALDH1A1SRCCA1 | |
| SCHEMBL29952661 | 0.78 | KMT2A (0.52) | ABCG2ERN1ALDH1A1SRCCA1 | |
| SCHEMBL18196756 | 0.78 | CA1 (0.59) | ERN1ALDH1A1SRCCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288933-B1 | OXINDOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | MUSC FOUND FOR RES DEV (US) | 2021-10-06 | — | — | EP | disclosed |
| US-10370328-B2 | Oxindole compounds and pharmaceutical compositions thereof | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2019-08-06 | — | — | US | disclosed |
| US-20180134659-A1 | OXINDOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT | 2018-05-17 | — | — | US | disclosed |
| EP-3288933-A1 | OXINDOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | Musc Foundation for Research Development (US) | 2018-03-07 | — | — | EP | disclosed |
| WO-2016176420-A1 | OXINDOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2016-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10370328-B2 | Oxindole compounds and pharmaceutical compositions thereof | PARK7, OPRK1, COMT | ABCG2 77/4885ERN1 3866/4885ALDH1A1 212/4885 |
| US-20180134659-A1 | OXINDOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PARK7, OPRK1, COMT | ABCG2 77/4885ERN1 3866/4885ALDH1A1 212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.