SCHEMBL18190856

SCHEMBL18190856

CC(C)COC(=O)N(CC(C)(C)C(=O)O)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.43
ALDH1A1 P00352 5/20 0.43
TSHR P16473 3/20 0.43
SMN1; SMN2 Q16637 4/20 0.42
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
TACR3 P29371 1/20 0.41
CHRNB2 P17787 1/20 0.41
CHRNB4 P30926 1/20 0.41
CHRNA3 P32297 1/20 0.41
CHRNA4 P43681 1/20 0.41
GAA P10253 1/20 0.40
MAPK1 P28482 1/20 0.40
NR1H3 Q13133 1/20 0.40
ELANE P08246 1/20 0.39
GLA P06280 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9601026 0.80 ALDH1A1 (0.47) MAPTALDH1A1TSHRSMN1; SMN2TACR3
SCHEMBL3483620 0.80 ALDH1A1 (0.47) MAPTALDH1A1TSHRSMN1; SMN2MEN1
SCHEMBL28207526 0.78 CHRM2 (0.52) ALDH1A1TSHRSMN1; SMN2CHRNB2CHRNB4
SCHEMBL5188456 0.73 ALDH1A1 (0.46) MAPTALDH1A1TSHRSMN1; SMN2MEN1
SCHEMBL18570091 0.68 PTGIR (0.46) MAPTALDH1A1TSHRSMN1; SMN2KMT2A
SCHEMBL4017485 0.67 ALDH1A1 (0.50) ALDH1A1TSHRMEN1KMT2ACHRNB2
SCHEMBL16964924 0.67 ATM (0.47) ALDH1A1TSHRSMN1; SMN2KMT2ACHRNB2
SCHEMBL1836904 0.66 ALDH1A1 (0.49) MAPTALDH1A1TSHRSMN1; SMN2MEN1
SCHEMBL12414758 0.66 ALDH1A1 (0.49) ALDH1A1TSHRSMN1; SMN2CYP3A4CYP2C9
SCHEMBL8113276 0.66 ADRA2C (0.43) MAPTALDH1A1TSHRGLAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3265448-A1 RILUZOLE PRODRUGS AND THEIR USE Biohaven Pharmaceutical Holding Company Ltd. (US) 2018-01-10 EP disclosed
WO-2016140879-A9 RILUZOLE PRODRUGS AND THEIR USE BIOHAVEN PHARMACEUTICAL HOLDING COMPANY LTD. (US) 2016-11-03 WO disclosed