Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MET | P08581 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2495841 | 0.73 | MET (0.72) | METALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL12369221 | 0.70 | MET (0.47) | METALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL18197881 | 0.68 | MET (0.55) | METALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL8087428 | 0.68 | POLB (0.76) | POLBALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL8094050 | 0.68 | POLB (0.76) | POLBALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL44366 | 0.68 | POLB (0.76) | POLBALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL27543185 | 0.66 | POLB (0.62) | POLBALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL177815 | 0.66 | POLB (0.67) | POLBALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL7823769 | 0.66 | POLB (0.49) | POLBALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL177812 | 0.66 | POLB (1.00) | POLBALDH1A1SMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966214-B9 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-13 | — | — | EP | disclosed |
| EP-1966214-B1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-02 | — | — | EP | disclosed |