Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 3/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL749848 | 0.75 | ALDH1A1 (0.51) | SCN5AL3MBTL1KDM4EALDH1A1MAPT | |
| SCHEMBL18197877 | 0.72 | MET (0.67) | METNQO2PDE3BPDE3APIP4K2C | |
| SCHEMBL2499862 | 0.72 | FYN (0.46) | SCN5AL3MBTL1METKDM4ECYP1A2 | |
| SCHEMBL14030430 | 0.72 | MEN1 (0.47) | SCN5AKDM4EALDH1A1MEN1LMNA | |
| SCHEMBL29726347 | 0.69 | KDM4E (0.36) | EGLN2KDM4EHPGDDYRK1APDE4A | |
| SCHEMBL2324555 | 0.66 | CA4 (0.54) | AHRLMNAHTT | |
| SCHEMBL11950451 | 0.63 | L3MBTL1 (0.48) | SCN5AL3MBTL1KDM4EALDH1A1MAPT | |
| SCHEMBL19338489 | 0.63 | MKNK1 (0.38) | EGLN2KDM4EDYRK1APDE4APDE4B | |
| SCHEMBL25415730 | 0.62 | JAK1 (0.50) | L3MBTL1EGLN2KDM4EALDH1A1MAPT | |
| SCHEMBL2390836 | 0.62 | KCNN4 (0.46) | AHRKDM4EALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966214-B9 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-13 | — | — | EP | disclosed |
| EP-1966214-B1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-02 | — | — | EP | disclosed |