Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17229875 | 0.90 | SLC6A2 (0.55) | HTR1ASLC6A2SLC6A4SLC6A3OPRL1 | |
| Hydrochloric Acid SCHEMBL29915703 | 0.88 | SLC6A2 (0.54) | HTR1ASLC6A2SLC6A4SLC6A3OPRL1 | |
| Hydrochloric Acid SCHEMBL17222951 | 0.88 | SLC6A2 (0.54) | HTR1ASLC6A2SLC6A4SLC6A3OPRL1 | |
| SCHEMBL1824314 | 0.83 | CHRNB2 (0.49) | CHRNB2CHRNA4HTR1ASLC6A2SLC6A4 | |
| SCHEMBL1822134 | 0.83 | HTR3A (0.49) | HTR3AHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27880809 | 0.82 | HTR1A (0.50) | CHRNB2CHRNA4HTR1ASLC6A2SLC6A4 | |
| SCHEMBL3333986 | 0.82 | HTR1A (0.50) | CHRNB2CHRNA4HTR1ASLC6A2SLC6A4 | |
| SCHEMBL29698867 | 0.82 | HTR1A (0.50) | CHRNB2CHRNA4HTR1ASLC6A2SLC6A4 | |
| SCHEMBL22608987 | 0.81 | CHRNB2 (0.47) | CHRNB2CHRNA4HTR3A | |
| Hydrochloric Acid SCHEMBL3932246 | 0.81 | HTR1A (0.49) | CHRNB2CHRNA4HTR1ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155669-B1 | NEW DISUBSTITUTED PHENYLPYRROLIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION | NSAB AF NEUROSEARCH SWEDEN AB (DK) | 2011-05-04 | — | — | EP | disclosed |
| US-20100197760-A1 | DISUBSTITUTED PHENYLPYRROLIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2010-08-05 | — | — | US | disclosed |
| CN-101711234-A | New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission | NSAB OF NEUROSEARCH SWEDEN AB | 2010-05-19 | — | — | CN | disclosed |
| EP-2155669-A1 | NEW DISUBSTITUTED PHENYLPYRROLIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION | NSAB, Filial af NeuroSearch Sweden AB, Sverige (DK) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008148799-A1 | NEW DISUBSTITUTED PHENYLPYRROLIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION | NSAB, FILIAL OF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2008-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197760-A1 | DISUBSTITUTED PHENYLPYRROLIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION | SLC6A2, SLC6A3, SLC18A2 | CHRNB2 33/4885CHRNA4 18/4885HTR3A 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.