Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18188997 | 0.87 | PDE4A (0.52) | CYP3A4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16072689 | 0.81 | ELANE (0.45) | MTNR1AMTNR1BELANEBRD4ALDH1A1 | |
| SCHEMBL16072690 | 0.81 | ALDH1A1 (0.47) | MTNR1AMTNR1BELANEHTR2AALDH1A1 | |
| SCHEMBL18188999 | 0.78 | CYP3A4 (0.50) | CYP3A4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16785675 | 0.78 | TNFSF11 (0.42) | MTNR1AMTNR1BCYP3A4ELANESTING1 | |
| SCHEMBL16785673 | 0.78 | TNFSF11 (0.42) | MTNR1AMTNR1BCYP3A4ELANESTING1 | |
| SCHEMBL13337963 | 0.77 | ELANE (0.51) | MTNR1AMTNR1BELANEKDM4EBRD4 | |
| SCHEMBL18200159 | 0.76 | MTNR1A (0.42) | MTNR1AMTNR1BELANEKDM4EBRD4 | |
| SCHEMBL95746 | 0.75 | PDE4A (0.64) | CYP3A4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16072691 | 0.75 | MTNR1A (0.41) | MTNR1AMTNR1BELANEALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288933-B1 | OXINDOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | MUSC FOUND FOR RES DEV (US) | 2021-10-06 | — | — | EP | disclosed |
| US-10370328-B2 | Oxindole compounds and pharmaceutical compositions thereof | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2019-08-06 | — | — | US | disclosed |
| US-20180134659-A1 | OXINDOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT | 2018-05-17 | — | — | US | disclosed |
| US-20180134659-A1 | OXINDOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT | 2018-05-17 | — | — | US | disclosed |
| WO-2016176420-A1 | OXINDOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2016-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10370328-B2 | Oxindole compounds and pharmaceutical compositions thereof | PARK7, OPRK1, COMT | MTNR1A 66/4885MTNR1B 44/4885CYP3A4 245/4885 |
| US-20180134659-A1 | OXINDOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PARK7, OPRK1, COMT | MTNR1A 66/4885MTNR1B 44/4885CYP3A4 245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.