Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR | Q13258 | 3/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | MAP2 | P11137 | 2/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | HTR7 | P34969 | 3/20 | 0.34 |
| ▸ | HTR6 | P50406 | 3/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | CTSC | P53634 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18210772 | 0.84 | HTR6 (0.46) | PTGDRDRD2HTR1AHTR2AHTR7 | |
| SCHEMBL24625570 | 0.74 | GAA (0.39) | RXRAGRIN1GRIN2B | |
| SCHEMBL16001188 | 0.70 | SIRT6 (0.43) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL1709030 | 0.70 | MAPT (0.57) | — | |
| SCHEMBL11291219 | 0.70 | ALDH1A1 (0.43) | HTR7 | |
| SCHEMBL3469564 | 0.70 | MAPK1 (0.43) | CCR1HTR7 | |
| SCHEMBL19692631 | 0.69 | AR (0.47) | HTR2AHTR6CTSKCTSC | |
| SCHEMBL16001227 | 0.68 | SIRT6 (0.46) | PTGDRHTR6 | |
| SCHEMBL21378854 | 0.68 | HTR6 (0.50) | HTR6CTSK | |
| SCHEMBL14923962 | 0.67 | PANK3 (0.43) | CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9486422-B2 | Small molecule inhibitors of Mcl-1 and the uses of thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-11-08 | — | — | US | disclosed |