Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.46 |
| ▸ | HTR1A | P08908 | 5/20 | 0.46 |
| ▸ | DRD2 | P14416 | 5/20 | 0.46 |
| ▸ | HTR2A | P28223 | 5/20 | 0.46 |
| ▸ | HTR7 | P34969 | 5/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18210663 | 0.84 | PTGDR (0.39) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL16001227 | 0.83 | SIRT6 (0.46) | HTR6SIRT6HTR3AGAAKDM4E | |
| SCHEMBL24783778 | 0.83 | SIRT6 (0.58) | HTR6HTR1ADRD2HTR2ASIRT6 | |
| SCHEMBL15283334 | 0.82 | GAA (0.58) | HTR6SIRT6HTR3AGAAKDM4E | |
| SCHEMBL16001188 | 0.79 | SIRT6 (0.43) | HTR6HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL25699466 | 0.79 | MAPT (0.49) | HTR6SIRT6HTR3AGAAKDM4E | |
| SCHEMBL15283363 | 0.79 | MAPT (0.54) | HTR6SIRT6HTR3AGAAKDM4E | |
| SCHEMBL15283343 | 0.77 | MAPT (0.52) | SIRT6HTR3AGAAKDM4EMAPT | |
| SCHEMBL8322549 | 0.77 | HTR3A (0.55) | HTR1ADRD2SIRT6HTR3AGAA | |
| SCHEMBL15283456 | 0.76 | SIRT6 (0.74) | HTR6SIRT6MAPTMAPK1PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9486422-B2 | Small molecule inhibitors of Mcl-1 and the uses of thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-11-08 | — | — | US | disclosed |