Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21888971 | 0.76 | POLB (0.33) | POLBNPC1PKMRAB9A | |
| SCHEMBL20464252 | 0.75 | ALDH1A1 (0.34) | — | |
| SCHEMBL13034606 | 0.65 | KMT2A (0.39) | POLB | |
| SCHEMBL13034396 | 0.65 | KMT2A (0.39) | POLB | |
| SCHEMBL19245759 | 0.62 | CNR2 (0.30) | — | |
| SCHEMBL16024980 | 0.62 | — | — | |
| SCHEMBL20166323 | 0.62 | APLNR (0.56) | — | |
| SCHEMBL20190046 | 0.62 | APLNR (0.56) | — | |
| SCHEMBL21581041 | 0.61 | RAB9A (0.33) | NPC1RAB9A | |
| SCHEMBL18984999 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016177686-A1 | PYRIDAZINE DERIVATIVES AS RORc MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-11-10 | — | — | WO | disclosed |