SCHEMBL18215475

SCHEMBL18215475

CCO[C@@H](C)CN(C)[SH](=O)=O

nearest known ligand 0.36

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.36
THRB P10828 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1097900 0.78
SCHEMBL18215486 0.76
SCHEMBL18312406 0.76 THRB (0.31) THRB
SCHEMBL18215559 0.76 LMNA (0.35) LMNATHRB
SCHEMBL18313003 0.72
SCHEMBL18215499 0.71 LMNA (0.31) LMNA
SCHEMBL18312468 0.70 MMP1 (0.34) LMNA
SCHEMBL18507948 0.69 LMNA (0.41) LMNATHRB
SCHEMBL27135950 0.69
SCHEMBL22435217 0.68 LMNA (0.36) LMNATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016201225-A1 ARYL DIHYDRO-2H-BENZO[B][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORY AND THE TREATMENT OF DISEASE LYCERA CORPORATION (US) 2016-12-15 WO disclosed
WO-2016179343-A1 DIHYDRO-2H-BENZO[b][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATMENT OF DISEASE LYCERA CORPORATION (US) 2016-11-10 WO disclosed