Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 14/20 | 0.57 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.56 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CCR3 | P51677 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13003260 | 0.78 | SIGMAR1 (0.68) | SIGMAR1SLC6A12TMEM97MCHR1MAOB | |
| SCHEMBL5402061 | 0.75 | SIGMAR1 (0.68) | SIGMAR1SLC6A12TMEM97MCHR1KMT2A | |
| SCHEMBL18658336 | 0.73 | SIGMAR1 (0.71) | SIGMAR1SLC6A12TMEM97MCHR1KMT2A | |
| SCHEMBL3997295 | 0.73 | SIGMAR1 (0.62) | SIGMAR1SLC6A12TMEM97MCHR1KMT2A | |
| SCHEMBL5862050 | 0.72 | SIGMAR1 (1.00) | SIGMAR1CCR3 | |
| SCHEMBL1425074 | 0.72 | SIGMAR1 (1.00) | SIGMAR1SLC6A12TMEM97MCHR1KMT2A | |
| SCHEMBL8037825 | 0.72 | SIGMAR1 (1.00) | SIGMAR1CCR3 | |
| SCHEMBL18658299 | 0.72 | SIGMAR1 (0.65) | SIGMAR1SLC6A12TMEM97MCHR1CCR3 | |
| SCHEMBL17803188 | 0.72 | SIGMAR1 (0.68) | SIGMAR1SLC6A12TMEM97MCHR1POLB | |
| Hydrochloric Acid SCHEMBL9785680 | 0.72 | SIGMAR1 (0.97) | SIGMAR1SLC6A12TMEM97MCHR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401268-B1 | OXYINDOLE DERIVATIVES WITH MOTILIN RECEPTOR AGONISTIC ACTIVITY | RAQUALIA PHARMA INC (JP) | 2015-07-29 | — | — | EP | disclosed |
| US-8697877-B2 | Oxyindole derivatives with motilin receptor agonistic activity | RAQUALIA PHARMA INC. (JP) | 2014-04-15 | — | — | US | disclosed |
| EP-2401268-A1 | OXYINDOLE DERIVATIVES WITH MOTILIN RECEPTOR AGONISTIC ACTIVITY | RaQualia Pharma Inc (JP) | 2012-01-04 | — | — | EP | disclosed |
| US-20110312933-A1 | OXYINDOLE DERIVATIVES WITH MOTILIN RECEPTOR AGONISTIC ACTIVITY | RAQUALIA PHARMA INC. (JP) | 2011-12-22 | — | — | US | disclosed |
| WO-2010098145-A1 | OXYINDOLE DERIVATIVES WITH MOTILIN RECEPTOR AGONISTIC ACTIVITY | RAQUALIA PHARMA INC. (JP) | 2010-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312933-A1 | OXYINDOLE DERIVATIVES WITH MOTILIN RECEPTOR AGONISTIC ACTIVITY | GPR68, GPR88, GPR52 | SIGMAR1 138/4885SLC6A12 1260/4885TMEM97 136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.