Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | EIF4A1 | P60842 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20176719 | 0.91 | SMN1; SMN2 (0.32) | SMN1; SMN2PTPN1EIF4A1ALDH1A1LMNA | |
| SCHEMBL20176716 | 0.91 | SMN1; SMN2 (0.32) | SMN1; SMN2ALDH1A1LMNAPOLBHTT | |
| SCHEMBL18217174 | 0.89 | KDM4E (0.32) | SMN1; SMN2PTPN1EIF4A1 | |
| SCHEMBL20176728 | 0.88 | SMN1; SMN2 (0.32) | SMN1; SMN2ALDH1A1LMNAPOLBHTT | |
| SCHEMBL21241720 | 0.86 | PTPN1 (0.37) | SMN1; SMN2PTPN1EIF4A1ALDH1A1LMNA | |
| SCHEMBL20182413 | 0.86 | SMN1; SMN2 (0.30) | SMN1; SMN2 | |
| SCHEMBL20176717 | 0.86 | KDM4E (0.41) | SMN1; SMN2PTPN1EIF4A1ALDH1A1LMNA | |
| SCHEMBL18217198 | 0.86 | ALOX15B (0.32) | SMN1; SMN2PTPN1HTTL3MBTL1 | |
| SCHEMBL19798373 | 0.85 | SMN1; SMN2 (0.32) | SMN1; SMN2ALDH1A1LMNAPOLBHTT | |
| SCHEMBL18217140 | 0.84 | GCGR (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10738240-B2 | Thiadiazoloquinoxaline derivatives | MERCK PATENT GMBH (DE) | 2020-08-11 | — | — | US | disclosed |
| US-20180142153-A1 | THIADIAZOLOQUINOXALINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-24 | — | — | US | disclosed |
| US-20180142153-A1 | THIADIAZOLOQUINOXALINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-24 | — | — | US | disclosed |
| WO-2016177449-A1 | THIADIAZOLOQUINOXALINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-11-10 | — | — | WO | disclosed |