Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15B | O15296 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ADK | P55263 | 1/20 | 0.30 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.30 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20176731 | 0.89 | GLA (0.31) | ALOX15BALOX12GLATSHRHTT | |
| SCHEMBL20176736 | 0.88 | ALOX15B (0.38) | ALOX15BALOX12ADKCYP17A1CYP11B1 | |
| SCHEMBL18217176 | 0.86 | — | — | |
| SCHEMBL18217156 | 0.86 | SMN1; SMN2 (0.32) | HTTL3MBTL1SMN1; SMN2PTPN1 | |
| SCHEMBL20176719 | 0.85 | SMN1; SMN2 (0.32) | HTTL3MBTL1SMN1; SMN2PTPN1 | |
| SCHEMBL18217174 | 0.83 | KDM4E (0.32) | SMN1; SMN2PTPN1 | |
| SCHEMBL21241720 | 0.83 | PTPN1 (0.37) | HTTL3MBTL1SMN1; SMN2PTPN1 | |
| SCHEMBL20176728 | 0.83 | SMN1; SMN2 (0.32) | HTTL3MBTL1SMN1; SMN2 | |
| SCHEMBL19798373 | 0.80 | SMN1; SMN2 (0.32) | HTTL3MBTL1SMN1; SMN2 | |
| SCHEMBL18217194 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10738240-B2 | Thiadiazoloquinoxaline derivatives | MERCK PATENT GMBH (DE) | 2020-08-11 | — | — | US | disclosed |
| US-20180142153-A1 | THIADIAZOLOQUINOXALINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-24 | — | — | US | disclosed |
| US-20180142153-A1 | THIADIAZOLOQUINOXALINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-24 | — | — | US | disclosed |
| WO-2016177449-A1 | THIADIAZOLOQUINOXALINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-11-10 | — | — | WO | disclosed |