Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18217156 | 0.88 | SMN1; SMN2 (0.32) | SMN1; SMN2ALDH1A1LMNAPOLBHTT | |
| SCHEMBL20176719 | 0.88 | SMN1; SMN2 (0.32) | SMN1; SMN2ALDH1A1LMNAPOLBHTT | |
| SCHEMBL21241720 | 0.87 | PTPN1 (0.37) | SMN1; SMN2ALDH1A1LMNAPOLBHTT | |
| SCHEMBL18217189 | 0.87 | BDKRB2 (0.33) | SMN1; SMN2BDKRB2 | |
| SCHEMBL19798373 | 0.86 | SMN1; SMN2 (0.32) | SMN1; SMN2ALDH1A1LMNAPOLBHTT | |
| SCHEMBL18217174 | 0.86 | KDM4E (0.32) | SMN1; SMN2KDM4E | |
| SCHEMBL20176727 | 0.85 | RAB9A (0.42) | SMN1; SMN2ALDH1A1LMNAL3MBTL1KDM4E | |
| SCHEMBL18217165 | 0.84 | — | — | |
| SCHEMBL18217198 | 0.83 | ALOX15B (0.32) | SMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL20176716 | 0.79 | SMN1; SMN2 (0.32) | SMN1; SMN2BDKRB2ALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10738240-B2 | Thiadiazoloquinoxaline derivatives | MERCK PATENT GMBH (DE) | 2020-08-11 | — | — | US | disclosed |
| US-20180142153-A1 | THIADIAZOLOQUINOXALINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-24 | — | — | US | disclosed |
| US-20180142153-A1 | THIADIAZOLOQUINOXALINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-24 | — | — | US | disclosed |