Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20176728 | 0.87 | SMN1; SMN2 (0.32) | BDKRB2SMN1; SMN2 | |
| SCHEMBL20176730 | 0.86 | KDM4E (0.31) | — | |
| SCHEMBL20176716 | 0.85 | SMN1; SMN2 (0.32) | BDKRB2SMN1; SMN2 | |
| SCHEMBL18217182 | 0.84 | SMN1; SMN2 (0.32) | BDKRB2SMN1; SMN2 | |
| SCHEMBL20176726 | 0.84 | — | — | |
| SCHEMBL20176727 | 0.83 | RAB9A (0.42) | SMN1; SMN2 | |
| SCHEMBL21019972 | 0.83 | SMN1; SMN2 (0.32) | BDKRB2SMN1; SMN2 | |
| SCHEMBL20176731 | 0.83 | GLA (0.31) | — | |
| SCHEMBL18418550 | 0.81 | BDKRB2 (0.38) | BDKRB2SMN1; SMN2 | |
| SCHEMBL20182413 | 0.81 | SMN1; SMN2 (0.30) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10738240-B2 | Thiadiazoloquinoxaline derivatives | MERCK PATENT GMBH (DE) | 2020-08-11 | — | — | US | disclosed |
| US-20180142153-A1 | THIADIAZOLOQUINOXALINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-24 | — | — | US | disclosed |
| US-20180142153-A1 | THIADIAZOLOQUINOXALINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-24 | — | — | US | disclosed |
| WO-2016177449-A1 | THIADIAZOLOQUINOXALINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-11-10 | — | — | WO | disclosed |