Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | RARB | P10826 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RARA | P10276 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20176717 | 0.86 | KDM4E (0.41) | RAB9AKDM4EMAPTHSD17B10ALDH1A1 | |
| SCHEMBL17694341 | 0.86 | KDM4E (0.43) | RAB9AKDM4EMAPTHSD17B10ALDH1A1 | |
| SCHEMBL20176724 | 0.85 | KDM4E (0.40) | RAB9AKDM4EMAPTHSD17B10ALDH1A1 | |
| SCHEMBL20176733 | 0.83 | KDM4E (0.39) | RAB9AKDM4EMAPTHSD17B10ALDH1A1 | |
| SCHEMBL18217189 | 0.83 | BDKRB2 (0.33) | SMN1; SMN2 | |
| SCHEMBL16546613 | 0.83 | KDM4E (0.40) | RAB9AKDM4EMAPTHSD17B10ALDH1A1 | |
| SCHEMBL20176729 | 0.82 | RARB (0.35) | RAB9AKDM4ERARBRARAESR1 | |
| SCHEMBL17694344 | 0.80 | RARB (0.38) | RAB9AKDM4EMAPTHSD17B10ALDH1A1 | |
| SCHEMBL20176736 | 0.80 | ALOX15B (0.38) | RAB9AKDM4EHSD11B1PTPN1EIF4A1 | |
| SCHEMBL19798374 | 0.80 | RAB9A (0.40) | RAB9AKDM4EMAPTHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180142153-A1 | THIADIAZOLOQUINOXALINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-24 | — | — | US | disclosed |