SCHEMBL1822086

SCHEMBL1822086

CCOC(=O)c1cc2cc(OC(=O)O)[nH]c2cc1Cl

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.44
CYP4F2 P78329 1/20 0.43
CYP4A11 Q02928 1/20 0.43
BAZ2B Q9UIF8 1/20 0.43
BAZ2A Q9UIF9 1/20 0.43
CA1 P00915 2/20 0.42
CA2 P00918 2/20 0.42
CA12 O43570 1/20 0.42
CA9 Q16790 1/20 0.42
ALDH1A1 P00352 5/20 0.42
KDM4E B2RXH2 5/20 0.42
MAPT P10636 3/20 0.42
KMT2A Q03164 3/20 0.42
LMNA P02545 3/20 0.42
HPGD P15428 3/20 0.42
RAB9A P51151 3/20 0.42
NPC1 O15118 3/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
GAA P10253 2/20 0.42
MEN1 O00255 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12494145 0.87 KDM4E (0.42) ALOX15ALDH1A1KDM4EMAPTKMT2A
SCHEMBL1822084 0.81 ALOX15 (0.56) ALOX15CYP4F2CYP4A11BAZ2BBAZ2A
SCHEMBL15567799 0.79 GLP1R (0.48) ALOX15ALDH1A1MAPTLMNANPC1
SCHEMBL2309931 0.77 ALDH1A1 (0.57) ALOX15BAZ2BBAZ2AALDH1A1KDM4E
SCHEMBL31345632 0.77 ALDH1A1 (0.57) ALOX15BAZ2BBAZ2AALDH1A1KDM4E
SCHEMBL3542541 0.76 ALOX15 (0.63) ALOX15ALDH1A1KDM4EMAPTKMT2A
SCHEMBL9233312 0.75 ALOX15 (0.39) ALOX15ALDH1A1KDM4EMAPTKMT2A
SCHEMBL4699958 0.75 ALDH1A1 (0.55) ALOX15BAZ2BBAZ2AALDH1A1KDM4E
SCHEMBL9234544 0.75 ALDH1A1 (0.39) ALDH1A1KDM4ELMNAHPGDHSD17B10
SCHEMBL12495308 0.74 DYRK1A (0.39) ALDH1A1KDM4EMAPTKMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2683688-B1 INDOLECARBOXAMIDES AND BENZIMIDAZOLECARBOXAMIDES AS INSECTICIDES AND ACARICIDES BAYER IP GMBH (DE) 2015-05-06 EP claimed
EP-2683688-A1 INDOLECARBOXAMIDES AND BENZIMIDAZOLECARBOXAMIDES AS INSECTICIDES AND ACARICIDES Bayer Intellectual Property GmbH (DE) 2014-01-15 EP claimed
WO-2012119984-A1 INDOLECARBOXAMIDES AND BENZIMIDAZOLECARBOXAMIDES AS INSECTICIDES AND ACARICIDES BAYER CROPSCIENCE AG (DE) 2012-09-13 WO claimed
EP-2683688-B1 INDOLECARBOXAMIDES AND BENZIMIDAZOLECARBOXAMIDES AS INSECTICIDES AND ACARICIDES BAYER IP GMBH (DE) 2015-05-06 EP disclosed
EP-2683688-A1 INDOLECARBOXAMIDES AND BENZIMIDAZOLECARBOXAMIDES AS INSECTICIDES AND ACARICIDES Bayer Intellectual Property GmbH (DE) 2014-01-15 EP disclosed
WO-2012119984-A1 INDOLECARBOXAMIDES AND BENZIMIDAZOLECARBOXAMIDES AS INSECTICIDES AND ACARICIDES BAYER CROPSCIENCE AG (DE) 2012-09-13 WO disclosed
EP-2493844-A2 HALOGENALKYL-SUBSTITUTED AMIDES USED AS INSECTICIDES AND ACARICIDES Bayer CropScience AG (DE) 2012-09-05 EP disclosed
WO-2011054436-A2 HALOGENALKYL-SUBSTITUTED AMIDES USED AS INSECTICIDES AND ACARICIDES BAYER CROPSCIENCE AG (DE) 2011-05-12 WO disclosed