Flutolanil

Flutolanil

SCHEMBL18222334

CC(C)Oc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1.Cc1ccccc1C(=O)Nc1cccc(OC(C)C)c1

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KCNK3 O14649 7/20 0.59
KCNK9 Q9NPC2 7/20 0.59
PTGS1 P23219 1/20 0.58
RXFP1 Q9HBX9 3/20 0.56
F2R P25116 2/20 0.56
KMT2A Q03164 2/20 0.55
POLB P06746 1/20 0.55
MEN1 O00255 1/20 0.54
SMN1; SMN2 Q16637 2/20 0.52
ALDH1A1 P00352 1/20 0.52
PTPRC P08575 1/20 0.52
TP53 P04637 1/20 0.50
THRB P10828 1/20 0.50
HPGD P15428 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Flutolanil SCHEMBL29451184 0.94 KCNK3 (0.65) KCNK3KCNK9PTGS1RXFP1F2R
Flutolanil SCHEMBL8362549 0.94 KCNK3 (0.65) KCNK3KCNK9PTGS1RXFP1F2R
Flutolanil SCHEMBL18555 0.94 KCNK3 (0.65) KCNK3KCNK9PTGS1RXFP1F2R
Mepronil SCHEMBL20522512 0.89 KCNK3 (0.67) KCNK3KCNK9F2RKMT2APOLB
Mepronil SCHEMBL30731287 0.89 KCNK3 (0.67) KCNK3KCNK9F2RKMT2APOLB
Mepronil SCHEMBL18447 0.89 KCNK3 (0.67) KCNK3KCNK9F2RKMT2APOLB
Mepronil SCHEMBL29453871 0.89 KCNK3 (0.67) KCNK3KCNK9F2RKMT2APOLB
Mepronil SCHEMBL6429840 0.84 KCNK3 (0.61) KCNK3KCNK9F2RKMT2APOLB
SCHEMBL21652267 0.83 KCNK3 (0.56) KCNK3KCNK9PTGS1RXFP1KMT2A
SCHEMBL11204897 0.83 NPC1 (0.70) KCNK3KCNK9PTGS1RXFP1F2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2430921-B1 Substituted benzene fungicides DU PONT (US) 2017-07-05 EP claimed
EP-2430920-B1 Substituted benzene fungicides DU PONT (US) 2016-11-16 EP claimed