Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | FBP1 | P09467 | 3/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 8/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PI4KA | P42356 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31361560 | 0.88 | MAPT (0.62) | ALDH1A1GAASMN1; SMN2TGFBR1MAPT | |
| SCHEMBL19783113 | 0.85 | TGFBR1 (0.49) | ALDH1A1GAASMN1; SMN2HTTFBP1 | |
| SCHEMBL14726501 | 0.78 | ALDH1A1 (0.76) | ALDH1A1GAASMN1; SMN2HTTFBP1 | |
| SCHEMBL11796387 | 0.76 | TGFBR1 (0.56) | SMN1; SMN2TGFBR1MAPTPIK3CDPIK3CA | |
| SCHEMBL24358097 | 0.76 | TGFBR1 (0.41) | ALDH1A1GAASMN1; SMN2TGFBR1MAPT | |
| Bromide SCHEMBL29078717 | 0.75 | TGFBR1 (0.54) | SMN1; SMN2TGFBR1MAPTPIK3CDPIK3CA | |
| SCHEMBL13506384 | 0.74 | KDM4E (0.50) | ALDH1A1GAASMN1; SMN2HTTMAPT | |
| SCHEMBL31361561 | 0.73 | TGFBR1 (0.55) | SMN1; SMN2HTTTGFBR1MAPTPIK3CD | |
| SCHEMBL3737029 | 0.73 | TGFBR1 (0.55) | SMN1; SMN2HTTTGFBR1MAPTPIK3CD | |
| SCHEMBL18230501 | 0.73 | TGFBR1 (0.51) | TGFBR1MAPTPIK3CDPIK3CAPI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016183173-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions (US) | 2016-11-17 | — | — | WO | disclosed |
| WO-2016183173-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions (US) | 2016-11-17 | — | — | WO | disclosed |