Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 8/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PI4KA | P42356 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | ADAMTS13 | Q76LX8 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18230383 | 0.85 | ALDH1A1 (0.55) | TGFBR1PIK3CDPIK3CAPI4KAPIK3CG | |
| SCHEMBL31361560 | 0.82 | MAPT (0.62) | TGFBR1PIK3CDPIK3CAPI4KAPIK3CG | |
| SCHEMBL2590963 | 0.78 | ALDH1A1 (0.66) | CYP1A2MAPTALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL24358097 | 0.76 | TGFBR1 (0.41) | TGFBR1PIK3CDPIK3CAPI4KAPIK3CG | |
| SCHEMBL31361561 | 0.73 | TGFBR1 (0.55) | TGFBR1PIK3CDPIK3CAPI4KAPIK3CG | |
| SCHEMBL11796387 | 0.73 | TGFBR1 (0.56) | TGFBR1PIK3CDPIK3CAPI4KAPIK3CG | |
| SCHEMBL3737029 | 0.73 | TGFBR1 (0.55) | TGFBR1PIK3CDPIK3CAPI4KAPIK3CG | |
| Bromide SCHEMBL29078717 | 0.72 | TGFBR1 (0.54) | TGFBR1PIK3CDPIK3CAPI4KAPIK3CG | |
| SCHEMBL5669674 | 0.72 | TGFBR1 (0.50) | TGFBR1PIK3CDPIK3CAPI4KAPIK3CG | |
| SCHEMBL1850971 | 0.70 | TGFBR1 (0.51) | TGFBR1PIK3CDPIK3CAPI4KAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013508-A1 | SUBSTITUTED AMINOTHIAZOLES | BARUCH S. BLUMBERG INSTITUTE (US) | 2018-01-18 | — | — | WO | disclosed |