Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 3/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.43 |
| ▸ | MPL | P40238 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18230427 | 0.91 | ADORA1 (0.54) | ADORA2AADORA1TRPV4ADORA3MPL | |
| SCHEMBL18230228 | 0.90 | GCK (0.52) | ADORA2AADORA1TRPV4MEN1NPC1 | |
| SCHEMBL18230507 | 0.87 | PCSK9 (0.48) | PCSK9ADORA2AADORA1TRPV4MEN1 | |
| SCHEMBL18230222 | 0.87 | ADORA2A (0.48) | ADORA2AADORA1TRPV4MEN1NPC1 | |
| SCHEMBL18230312 | 0.87 | GCK (0.55) | ADORA2AADORA1TRPV4MEN1NPC1 | |
| SCHEMBL18230324 | 0.85 | TLR7 (0.54) | ADORA2AADORA1DHODHADORA3BRAF | |
| SCHEMBL18230402 | 0.84 | ADORA1 (0.55) | ADORA2AADORA1TRPV4MEN1NPC1 | |
| SCHEMBL18230391 | 0.83 | ADORA2A (0.49) | ADORA2AADORA1TRPV4DHODHADORA3 | |
| SCHEMBL18230521 | 0.82 | TRPV1 (0.59) | ADORA2AADORA1MEN1NPC1RAB9A | |
| SCHEMBL18230235 | 0.82 | ADORA3 (0.62) | ADORA2AADORA1TRPV4KMT2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016183173-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions (US) | 2016-11-17 | — | — | WO | disclosed |
| WO-2016183173-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions (US) | 2016-11-17 | — | — | WO | disclosed |