Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 6/20 | 0.55 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.49 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
| ▸ | LOX | P28300 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18230228 | 0.94 | GCK (0.52) | GCKTRPV4ADORA2AADORA1MEN1 | |
| SCHEMBL18230222 | 0.93 | ADORA2A (0.48) | GCKGRM1TRPV4ADORA2AADORA1 | |
| SCHEMBL18230402 | 0.88 | ADORA1 (0.55) | GRM1TRPV4ADORA2AADORA1MEN1 | |
| SCHEMBL18230522 | 0.87 | PCSK9 (0.50) | TRPV4ADORA2AADORA1MEN1NPC1 | |
| SCHEMBL18230382 | 0.85 | TRPV1 (0.53) | GRM1TRPV4ADORA2AADORA1MEN1 | |
| SCHEMBL18230491 | 0.85 | GRM1 (0.47) | GCKGRM1TRPV4ADORA2AADORA1 | |
| SCHEMBL18230324 | 0.82 | TLR7 (0.54) | ADORA2AADORA1DHODHADORA3 | |
| SCHEMBL18230427 | 0.81 | ADORA1 (0.54) | GRM1TRPV4ADORA2AADORA1ADORA3 | |
| SCHEMBL18094583 | 0.81 | GCK (0.58) | GCKGRM1ADORA3LOXLOXL2 | |
| SCHEMBL18230261 | 0.81 | ADORA3 (0.62) | TRPV4ADORA2AADORA1MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016183173-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions (US) | 2016-11-17 | — | — | WO | disclosed |
| WO-2016183173-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions (US) | 2016-11-17 | — | — | WO | disclosed |