Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | GCK | P35557 | 4/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | KDM4B | O94953 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18230228 | 0.94 | GCK (0.52) | ADORA2AADORA1GCKTRPV4ADORA3 | |
| SCHEMBL18230382 | 0.93 | TRPV1 (0.53) | ADORA2AADORA1TRPV1TRPV4ADORA3 | |
| SCHEMBL18230312 | 0.93 | GCK (0.55) | ADORA2AADORA1GCKTRPV4ADORA3 | |
| SCHEMBL18230402 | 0.90 | ADORA1 (0.55) | ADORA2AADORA1TRPV1TRPV4ADORA3 | |
| SCHEMBL18230521 | 0.87 | TRPV1 (0.59) | ADORA2AADORA1TRPV1ADORA3MEN1 | |
| SCHEMBL18230522 | 0.87 | PCSK9 (0.50) | ADORA2AADORA1TRPV4ADORA3MEN1 | |
| SCHEMBL18230324 | 0.86 | TLR7 (0.54) | ADORA2AADORA1TRPV1ADORA3DHODH | |
| SCHEMBL18094558 | 0.84 | MAPT (0.51) | GCKTRPV1ADORA3KDRKDM4A | |
| SCHEMBL18230427 | 0.83 | ADORA1 (0.54) | ADORA2AADORA1TRPV1TRPV4ADORA3 | |
| SCHEMBL18230261 | 0.82 | ADORA3 (0.62) | ADORA2AADORA1TRPV4ADORA3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016183173-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions (US) | 2016-11-17 | — | — | WO | disclosed |
| WO-2016183173-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions (US) | 2016-11-17 | — | — | WO | disclosed |