Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | NQO2 | P16083 | 5/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16845587 | 1.00 | KDM4E (0.48) | KDM4EL3MBTL1ALOX15NQO2NOTUM | |
| SCHEMBL16845583 | 0.83 | NQO2 (0.40) | KDM4ENQO2NOTUMSYKLMNA | |
| SCHEMBL16870491 | 0.81 | NQO2 (0.41) | KDM4ENQO2NOTUMSYKLMNA | |
| SCHEMBL112719 | 0.75 | KDM4E (0.45) | KDM4ENQO2NOTUMSYKLMNA | |
| SCHEMBL30307699 | 0.75 | KDM4E (0.45) | KDM4ENQO2NOTUMSYKLMNA | |
| SCHEMBL16398495 | 0.74 | NQO2 (0.35) | NQO2SYKLMNAALDH1A1MAPK1 | |
| SCHEMBL24046189 | 0.74 | NQO2 (0.43) | KDM4ENQO2NOTUMSYKLMNA | |
| SCHEMBL2706709 | 0.74 | LMNA (0.47) | KDM4EL3MBTL1ALOX15NQO2LMNA | |
| SCHEMBL350485 | 0.74 | ALDH1A1 (0.54) | KDM4ENQO2LMNAALDH1A1MAPK1 | |
| SCHEMBL10198533 | 0.74 | LMNA (0.47) | KDM4ENQO2NOTUMSYKLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9745287-B2 | Pyrimidines and use thereof | PURDUE PHARMA L.P. (US) | 2017-08-29 | — | — | US | disclosed |
| US-20160332992-A1 | PYRIMIDINES AND USE THEREOF | PURDUE PHARMA L.P. | 2016-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160332992-A1 | PYRIMIDINES AND USE THEREOF | ADORA2B, P2RX2, P2RX3 | KDM4E 3153/4885L3MBTL1 1036/4885ALOX15 2071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.