Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | EED | O75530 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18235038 | 0.84 | KCNA2 (0.42) | MAOBGLASTING1CES1KDM4E | |
| SCHEMBL18235040 | 0.84 | MAPT (0.40) | GLASTING1CES1KDM4EPOLB | |
| SCHEMBL18235041 | 0.82 | KDM4E (0.43) | MAOBGLASTING1CES1KDM4E | |
| SCHEMBL11616224 | 0.80 | MAOB (0.56) | MAOBGLASTING1CES1ALOX15 | |
| SCHEMBL28576970 | 0.78 | ALOX15 (0.60) | MAOBKDM4EALOX15ALOX12SMN1; SMN2 | |
| SCHEMBL30903607 | 0.78 | ALOX15 (0.60) | MAOBKDM4EALOX15ALOX12SMN1; SMN2 | |
| SCHEMBL18222932 | 0.76 | MAOB (0.44) | MAOBKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11538924 | 0.76 | CES1 (0.42) | MAOBCES1ALOX15ALOX12POLB | |
| SCHEMBL7052889 | 0.75 | MAOB (0.45) | MAOBGLASTING1CES1KDM4E | |
| SCHEMBL31556208 | 0.75 | MAOB (0.45) | MAOBGLASTING1CES1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9718799-B2 | 3-aryl-4H-chromene-4-ones as antineoplastic agents for the treatment of cancer | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2017-08-01 | — | — | US | disclosed |
| US-20160332981-A1 | 3-ARYL-4H-CHROMENE-4-ONES AS ANTINEOPLASTIC AGENTS FOR THE TREATMENT OF CANCER | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2016-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160332981-A1 | 3-ARYL-4H-CHROMENE-4-ONES AS ANTINEOPLASTIC AGENTS FOR THE TREATMENT OF CANCER | KLK3, NCOA3, CYP46A1 | MAOB 1324/4885GLA 1511/4885STING1 4752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.