Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10684674 | 0.90 | CA1 (0.46) | ALDH1A1CYP3A4CYP2C9CYP2C19CA1 | |
| Hydrochloric Acid SCHEMBL10685955 | 0.89 | CA1 (0.45) | ALDH1A1CYP3A4CYP2C9CYP2C19CA1 | |
| SCHEMBL4768191 | 0.84 | GAA (0.49) | ALDH1A1CYP3A4CYP2C9CYP2C19CA1 | |
| SCHEMBL10686079 | 0.83 | PSIP1 (0.47) | ALDH1A1CYP3A4CYP2C9CYP2C19PKM | |
| Hydrochloric Acid SCHEMBL10686023 | 0.82 | PSIP1 (0.46) | ALDH1A1CYP3A4CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL21386096 | 0.81 | ALDH1A1 (0.48) | ALDH1A1CYP3A4CYP2C9CYP2C19CA1 | |
| SCHEMBL4770148 | 0.79 | GAA (0.47) | ALDH1A1CYP3A4CYP2C9CYP2C19CA1 | |
| SCHEMBL10682145 | 0.79 | HDAC1 (0.49) | ALDH1A1CYP3A4CYP2C9CYP2C19PKM | |
| SCHEMBL18236771 | 0.79 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL15013716 | 0.78 | ALDH1A1 (0.56) | ALDH1A1CYP3A4CYP2C9CYP2C19CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951065-B2 | Benzimidazole and imadazopyridine carboximidamide compounds | GILEAD SCIENCES, INC. (US) | 2018-04-24 | — | — | US | disclosed |
| US-20160333009-A1 | BENZIMIDAZOLE AND IMADAZOPYRIDINE CARBOXIMIDAMIDE COMPOUNDS | GILEAD SCIENCES, INC. | 2016-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160333009-A1 | BENZIMIDAZOLE AND IMADAZOPYRIDINE CARBOXIMIDAMIDE COMPOUNDS | IDO1, IDO2, INMT | ALDH1A1 236/4885CYP3A4 245/4885CYP2C9 375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.