SCHEMBL182377

SCHEMBL182377

C/C=C/C(=O)OC(O)CC

nearest known ligand 0.39

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.39
HCAR2 Q8TDS4 2/20 0.34
ATM Q13315 1/20 0.30
GSTP1 P09211 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL182379 1.00 TSHR (0.39) TSHRHCAR2ATMGSTP1
SCHEMBL301455 0.89 TSHR (0.43) TSHRHCAR2ATM
SCHEMBL301454 0.89 TSHR (0.43) TSHRHCAR2ATM
SCHEMBL950768 0.89 TSHR (0.43) TSHRHCAR2ATM
SCHEMBL9160338 0.86 TSHR (0.34) TSHRHCAR2
SCHEMBL9160314 0.86 TSHR (0.34) TSHRHCAR2
SCHEMBL4613181 0.83 HCAR2 (0.32) TSHRHCAR2ATMGSTP1
SCHEMBL4613185 0.83 HCAR2 (0.32) TSHRHCAR2ATMGSTP1
SCHEMBL29221071 0.83 TSHR (0.39) TSHRHCAR2ATM
SCHEMBL8641563 0.81 HCAR2 (0.57) TSHRHCAR2ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6287723-B1 POLYMER OF ACRYLIC ESTER NIPPON ZEON CO., LTD. (JP) 2001-09-11 US claimed
EP-0411514-A2 Internally plasticized polyvinyl-halide compositions and articles prepared therefrom The Geon Company (US) 1991-02-06 EP claimed
US-4259460-A BLENDS OF POLYMERS OF VINYL CHLORIDE, ACRYLONITRILE-BUTADIENE, AND BUTADIENE-STYRENE-TERTIARY AMINE POLYSAR LIMITED (CA) 1981-03-31 US claimed
US-4150014-A HYDROXYL HYDROCARBYL POLYMER, AMINE, SHEARING POLYSAR LIMITED (CA) 1979-04-17 US claimed
US-4150015-A MONOAZO OR AZO-METHINE DYES REACTED WITH A 2-(CYCLOPENTAN-1-ON-2-YLIDENE)CHROMAN COMPOUND POLYSAR LIMITED (CA) 1979-04-17 US claimed
US-12201714-B2 Multicomponent pur composition WELLA INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) 2025-01-21 US disclosed
US-20240261213-A1 MULTICOMPONENT PUR COMPOSITION Wella International Operations Switzerland Sárl (CH) 2024-08-08 US disclosed
CN-117651545-A Method for activating and producing keratin fibre coating, preferably colour coating 威娜德国有限责任公司 2024-03-05 CN disclosed
US-11904042-B2 Hair coloring composition and methods for its application and removal HFC Prestige International Holding Switzerland S.a.r.l. (CH) 2024-02-20 US disclosed
US-11478415-B2 Multicomponent composition WELLA INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) 2022-10-25 US disclosed
US-11324688-B2 Bicomponent composition WELLA INTERNATIONAL OPERATIONS SWI (CH) 2022-05-10 US disclosed
US-20210290518-A1 MULTICOMPONENT COMPOSITION HFC PRESTIGE INTERNATIONAL OPERATIONS SWITZERLAND SARL (CH) 2021-09-23 US disclosed
US-4465794-A Hydrophilic polymers and contact lenses therefrom ALLERGAN 1984-08-14 US disclosed
US-4357432-A COPOLYENE/CONJUGATED/, STYRENE AND A HYDROXY OR GLYCIDYL GROUP POLYSAR LIMITED (CA) 1982-11-02 US disclosed
US-4328148-A SOLFTNESS AND WEAR RESISTANCE ACHIEVED BY THE USE OF AN ACRYLATE-ACRYLAMIDE POLYMEER ALLERGAN 1982-05-04 US disclosed
US-4275183-A Hydrophilic polymers and contact lenses therefrom ALLERGAN 1981-06-23 US disclosed
US-4259460-A BLENDS OF POLYMERS OF VINYL CHLORIDE, ACRYLONITRILE-BUTADIENE, AND BUTADIENE-STYRENE-TERTIARY AMINE POLYSAR LIMITED (CA) 1981-03-31 US disclosed
US-4150014-A HYDROXYL HYDROCARBYL POLYMER, AMINE, SHEARING POLYSAR LIMITED (CA) 1979-04-17 US disclosed
US-4150015-A MONOAZO OR AZO-METHINE DYES REACTED WITH A 2-(CYCLOPENTAN-1-ON-2-YLIDENE)CHROMAN COMPOUND POLYSAR LIMITED (CA) 1979-04-17 US disclosed
US-3935342-A POLYMERIZATION WITH AN UNSATURATED SILYL MONOMER MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) 1976-01-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11904042-B2 Hair coloring composition and methods for its application and removal KRT18, TYR, CD99 TSHR 1636/4885HCAR2 4156/4885ATM 2938/4885
US-11324688-B2 Bicomponent composition KRT18, EXOSC10, EXOSC9 TSHR 3398/4885HCAR2 4747/4885ATM 963/4885
US-20210290518-A1 MULTICOMPONENT COMPOSITION KRT18, INCENP, IK TSHR 3154/4885HCAR2 4691/4885ATM 3120/4885
US-12201714-B2 Multicomponent pur composition KRT18, EXOSC9, EXOSC4 TSHR 3746/4885HCAR2 4778/4885ATM 2979/4885
US-20240261213-A1 MULTICOMPONENT PUR COMPOSITION KRT18, EXOSC9, EXOSC4 TSHR 3746/4885HCAR2 4778/4885ATM 2979/4885
US-11478415-B2 Multicomponent composition KRT18, INCENP, IK TSHR 3154/4885HCAR2 4691/4885ATM 3120/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.