Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.56 |
| ▸ | NQO2 | P16083 | 2/20 | 0.56 |
| ▸ | CYP1A1 | P04798 | 5/20 | 0.55 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.52 |
| ▸ | TUBB | P07437 | 1/20 | 0.52 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.52 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.52 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.52 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.52 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.52 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.52 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3941687 | 0.86 | GAA (0.47) | GAATDP1ALDH1A1TSHRPTGS1 | |
| SCHEMBL3950600 | 0.86 | PDE4B (0.49) | GAATDP1ALDH1A1TSHRPTGS1 | |
| SCHEMBL1822805 | 0.86 | AMY1A (0.55) | GAATDP1ALDH1A1PTGS1TUBB1 | |
| SCHEMBL3757705 | 0.85 | ALDH1A1 (0.62) | ALDH1A1NQO2APPCYP1A2TUBB4A | |
| SCHEMBL13766033 | 0.84 | KDM4E (0.53) | GAATDP1ALDH1A1PTGS1TUBB4A | |
| SCHEMBL2172380 | 0.83 | TUBB1 (0.57) | GAATDP1PTGS1PTGS2NQO2 | |
| SCHEMBL23043041 | 0.82 | DRD2 (0.46) | GAATDP1ALDH1A1TSHRPTGS1 | |
| SCHEMBL18913433 | 0.82 | FDPS (0.53) | ALDH1A1PTGS1APPKDM4EHPGD | |
| SCHEMBL6710989 | 0.82 | GAA (0.44) | GAATDP1ALDH1A1TSHRPTGS1 | |
| SCHEMBL13370881 | 0.82 | GAA (0.68) | GAATDP1ALDH1A1TSHRPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324404-B2 | 3-thia-10-aza-phenanthrene derivatives | NYCOMED GMBH (DE) | 2012-12-04 | — | — | US | disclosed |
| US-8324404-B2 | 3-thia-10-aza-phenanthrene derivatives | NYCOMED GMBH (DE) | 2012-12-04 | — | — | US | disclosed |
| US-8324404-B2 | 3-thia-10-aza-phenanthrene derivatives | NYCOMED GMBH (DE) | 2012-12-04 | — | — | US | disclosed |
| US-8044061-B2 | Parkinson's disease, catalepsy, dystonia, dyskinetic syndrome, restless legs syndrome, migraine, pain, dementia, neurodegenerative disorders, alcohol withdrawal and/or ischemic conditions such as e.g. stroke or cardiac ischemia. | UCB PHARMA GMBH (DE) | 2011-10-25 | — | — | US | disclosed |
| EP-1797098-B1 | 3-OXA-10-AZA-PHENANTHRENES AS PDE4 OR PDE3/4 INHIBITORS | NYCOMED GMBH (DE) | 2011-05-04 | — | — | EP | disclosed |
| US-7838521-B2 | 3-oxa-10-aza-phenanthrenes | NYCOMED GMBH (DE) | 2010-11-23 | — | — | US | disclosed |
| US-7838521-B2 | 3-oxa-10-aza-phenanthrenes | NYCOMED GMBH (DE) | 2010-11-23 | — | — | US | disclosed |
| US-7838521-B2 | 3-oxa-10-aza-phenanthrenes | NYCOMED GMBH (DE) | 2010-11-23 | — | — | US | disclosed |
| EP-0701444-B1 | METHODS AND COMPOSITIONS FOR INDUCING SLEEP | PURDUE PHARMA LTD (US) | 2010-04-07 | — | — | EP | disclosed |
| US-20090239895-A1 | Novel 3-thia-10-aza-phenanthrene derivatives | NYCOMED GMBH (DE) | 2009-09-24 | — | — | US | disclosed |
| EP-0752860-B1 | ANDROSTANES AND PREGNANES FOR ALLOSTERIC MODULATION OF GABA RECEPTOR | EURO CELTIQUE SA (LU) | 2000-08-23 | — | — | EP | disclosed |
| US-5939545-A | MODULATING THE GABA.SUB.A (GAMMA-AMINOBUTYRIC ACID A) RECEPTOR-CHLORIDE IONOPHORE COMPLEX TO ALLEVIATE STRESS, ANXIETY, SEIZURES, MOOD DISORDERS, PMS (PREMENSTRUAL SYNDROME) AND PND (POSTNATAL DEPRESSION) AND TO INDUCE ANESTHESIA | COCENSYS, INC. (US) | 1999-08-17 | — | — | US | disclosed |
| EP-0752860-A4 | ANDROSTANES AND PREGNANES FOR ALLOSTERIC MODULATION OF GABA RECEPTOR | COCENSYS INC (US) | 1998-05-06 | — | — | EP | disclosed |
| EP-0752860-A1 | ANDROSTANES AND PREGNANES FOR ALLOSTERIC MODULATION OF GABA RECEPTOR | COCENSYS, INC. (US) | 1997-01-15 | — | — | EP | disclosed |
| EP-0701444-A1 | METHODS AND COMPOSITIONS FOR INDUCING SLEEP | COCENSYS, INC. (US) | 1996-03-20 | — | — | EP | disclosed |
| WO-1995021617-A1 | ANDROSTANES AND PREGNANES FOR ALLOSTERIC MODULATION OF GABA RECEPTOR | COCENSYS, INC. (US) | 1995-08-17 | — | — | WO | disclosed |
| WO-1994027608-A9 | METHODS AND COMPOSITIONS FOR INDUCING SLEEP | — | 1995-01-12 | — | — | WO | disclosed |
| WO-1994027608-A1 | METHODS AND COMPOSITIONS FOR INDUCING SLEEP | COCENSYS, INC. (US) | 1994-12-08 | — | — | WO | disclosed |
| US-4194002-A | Cholesterol ester-reducing amides of hexahydroindolinols | SANDOZ, INC. (US) | 1980-03-18 | — | — | US | disclosed |
| US-4129658-A | HYPOLIPIDEMIC, ANTIARRHYTHMIA | SANDOZ LTD. (CH) | 1978-12-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239895-A1 | Novel 3-thia-10-aza-phenanthrene derivatives | PDE4A, PDE4B, PDE3A | GAA 1655/4885TDP1 40/4885ALDH1A1 215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.