SCHEMBL18245481

SCHEMBL18245481

[C]#CCc1c(OC)ccc2ccccc12

nearest known ligand 0.53

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.53
KMT2A Q03164 4/20 0.51
MEN1 O00255 3/20 0.51
POLB P06746 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.47
KDM1A O60341 1/20 0.46
MAOA P21397 1/20 0.46
SLC6A4 P31645 1/20 0.45
CETP P11597 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18245047 0.84 KMT2A (0.50) MAPTKMT2AMEN1POLBSMN1; SMN2
SCHEMBL8710773 0.83 MAPT (0.53) MAPTKMT2AMEN1POLBSMN1; SMN2
SCHEMBL18244906 0.81 KMT2A (0.48) MAPTKMT2AMEN1POLBSMN1; SMN2
SCHEMBL19766698 0.80 MAPT (0.62) MAPTKMT2AMEN1POLBSMN1; SMN2
SCHEMBL18245166 0.80 SLC6A4 (0.49) MAPTKMT2AMEN1POLBSMN1; SMN2
SCHEMBL11893003 0.79 KMT2A (0.60) MAPTKMT2AMEN1POLBSMN1; SMN2
SCHEMBL5236602 0.77 MAPT (0.58) MAPTKMT2AMEN1POLBSMN1; SMN2
SCHEMBL4698919 0.77 MAPT (0.58) MAPTKMT2AMEN1POLBSMN1; SMN2
SCHEMBL29625776 0.77 MAPT (0.58) MAPTKMT2AMEN1POLBSMN1; SMN2
SCHEMBL19610235 0.77 MAPT (0.58) MAPTKMT2AMEN1POLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3098226-B1 BORATE-BASED BASE GENERATOR, AND BASE-REACTIVE COMPOSITION COMPRISING SUCH BASE GENERATOR FUJIFILM WAKO PURE CHEMICAL CORP (JP) 2018-12-12 EP disclosed
US-10100070-B2 Borate-based base generator, and base-reactive composition comprising such base generator FUJIFILM WAKO PURE CHEMICAL CORPORATION (JP) 2018-10-16 US disclosed
EP-3098226-A1 BORATE-BASED BASE GENERATOR, AND BASE-REACTIVE COMPOSITION COMPRISING SUCH BASE GENERATOR Wako Pure Chemical Industries, Ltd. (JP) 2016-11-30 EP disclosed
US-20160340374-A1 BORATE-BASED BASE GENERATOR, AND BASE-REACTIVE COMPOSITION COMPRISING SUCH BASE GENERATOR FUJIFILM WAKO PURE CHEMICAL CORPORATION (JP) 2016-11-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10100070-B2 Borate-based base generator, and base-reactive composition comprising such base generator BLM, HPRT1, BROX MAPT 2226/4885KMT2A 2230/4885MEN1 28/4885
US-20160340374-A1 BORATE-BASED BASE GENERATOR, AND BASE-REACTIVE COMPOSITION COMPRISING SUCH BASE GENERATOR ENPP3, GNG2, ENPP1 MAPT 3913/4885KMT2A 3459/4885MEN1 975/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.