Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.45 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.45 |
| ▸ | CETP | P11597 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28116865 | 0.84 | LMNA (0.47) | MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL18245481 | 0.83 | MAPT (0.53) | MAPTKMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL19766698 | 0.80 | MAPT (0.62) | MAPTKMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL17919669 | 0.80 | KDM2B (0.47) | — | |
| SCHEMBL11893003 | 0.79 | KMT2A (0.60) | MAPTKMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL19807283 | 0.78 | KDM2B (0.47) | — | |
| SCHEMBL8876872 | 0.78 | SMN1; SMN2 (0.54) | MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1254854 | 0.78 | KMT2A (0.61) | MAPTKMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL19610235 | 0.77 | MAPT (0.58) | MAPTKMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL5236602 | 0.77 | MAPT (0.58) | MAPTKMT2AMEN1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113527139-A | Method for synthesizing 7-methoxy-1-naphthylacetonitrile and intermediate | 上海法默生物科技有限公司 | 2021-10-22 | — | — | CN | disclosed |
| EP-3242872-B1 | (PIPERIDIN-3-YL)(NAPHTHALEN-2-YL)METHANONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HISTONE DEMETHYLASE KDM2B FOR THE TREATMENT OF CANCER | GENENTECH INC (US) | 2019-07-03 | — | — | EP | disclosed |
| CN-102452951-B | Agomelatine and pharmaceutical composition thereof | TIANJIN TAIPU PHARMACEUTICAL SCI & TECH DEV CO LTD | 2014-02-19 | — | — | CN | disclosed |
| US-8252951-B2 | Process for the synthesis of (methoxy-1-naphthyl) acetonitrile and application in the synthesis of agomelatine | LES LABORATOIRES SERVIER (FR) | 2012-08-28 | — | — | US | disclosed |
| US-5708020-A | FOR TREATING SLEEP DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-01-13 | — | — | US | disclosed |
| US-5604261-A | HAVING HYDROXYL/ALKOXYL GROUP ORTHO TO AMIDE GROUP ON PHENYL RING; HIGH MELATONIN RECEPTOR AFFINITY | ADIR ET COMPAGNIE (FR) | 1997-02-18 | — | — | US | disclosed |
| US-5554642-A | USE TO TREAT MAMMALS AFFLICTED WITH SLEEP DISORDERS | ADIR ET COMPAGNIE (FR) | 1996-09-10 | — | — | US | disclosed |
| EP-0591057-B1 | Arylalkyl(thio)amides with melatonine receptor selectivity and process for their preparation | ADIR (FR) | 1996-07-10 | — | — | EP | disclosed |
| US-5464872-A | Sleep disorders | ADIR ET COMPAGNIE (FR) | 1995-11-07 | — | — | US | disclosed |
| EP-0591057-A1 | Arylalkyl(thio)amides with melatonine receptor selectivity and process for their preparation | ADIR ET COMPAGNIE (FR) | 1994-04-06 | — | — | EP | disclosed |