Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 1/20 | 0.50 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | CTSC | P53634 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL1824936 | 1.00 | SCN4A (0.50) | SCN4AELANECTSCCYP2D6CYP1A2 | |
| Pipecolic Acid SCHEMBL28845013 | 0.95 | SLC6A3 (0.47) | SCN4ACYP2D6CYP3A4SLC6A2SLC6A3 | |
| Biphenyl SCHEMBL2308811 | 0.86 | ELANE (0.47) | SCN4AELANECTSCCYP2D6CYP1A2 | |
| Proline SCHEMBL16394427 | 0.85 | BLM (0.48) | SCN4AELANECTSCCYP2D6CYP1A2 | |
| Benzoic Acid SCHEMBL31591115 | 0.83 | DAO (0.48) | SCN4AELANECTSCCYP2D6CYP1A2 | |
| Ethylbenzene SCHEMBL1116548 | 0.82 | CTSC (0.49) | SCN4AELANECTSCHTR2CHTR2B | |
| Proline SCHEMBL7546264 | 0.82 | HTR2C (0.47) | SCN4AELANECTSCDPP4HTR2C | |
| Proline SCHEMBL3060992 | 0.82 | CYP2D6 (0.43) | SCN4ACYP2D6KDM4EMAPTNPC1 | |
| D-Proline SCHEMBL3803838 | 0.82 | CYP2D6 (0.43) | SCN4ACYP2D6KDM4EMAPTNPC1 | |
| Proline SCHEMBL9015317 | 0.81 | CTSC (0.51) | SCN4AELANECTSCHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113395898-A | Compositions for treating citrus disease and promoting yield enhancement of row crops | 斯波根生物技术公司 | 2021-09-14 | — | — | CN | claimed |
| EP-3606347-A1 | AGRICULTURAL COMPOSITIONS FOR IMPROVED CROP PRODUCTIVITY AND ENHANCED PHENOTYPES | Spogen Biotech Inc. (US) | 2020-02-12 | — | — | EP | claimed |
| WO-2018187345-A1 | AGRICULTURAL COMPOSITIONS FOR IMPROVED CROP PRODUCTIVITY AND ENHANCED PHENOTYPES | SPOGEN BIOTECH INC. (US) | 2018-10-11 | — | — | WO | claimed |
| US-20250241300-A1 | AGRICULTURAL COMPOSITIONS FOR IMPROVED CROP PRODUCTIVITY AND ENHANCED PHENOTYPES | SPOGEN BIOTECH INC. | 2025-07-31 | — | — | US | disclosed |
| US-12029175-B2 | Plant supplement delivery assemblies, and methods for delivering plant supplements | BATTELLE MEMORIAL INSTITUTE (US) | 2024-07-09 | — | — | US | disclosed |
| CN-118238242-A | Dry lawn coloring agent and application thereof | 郑州郑氏化工产品有限公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-115807017-B | Application of tomato gene SlMAPK12 in regulation and control of drought resistance of tomatoes | 福建师范大学 | 2024-06-18 | — | — | CN | disclosed |
| CN-114989276-B | Perilla salt tolerance related protein PfWRKY33, and coding gene and application thereof | 湖南文理学院 | 2023-07-14 | — | — | CN | disclosed |
| CN-115807017-A | Application of tomato gene SlMAPK12 in regulation and control of tomato drought resistance | 福建师范大学 | 2023-03-17 | — | — | CN | disclosed |
| CN-112981000-B | InDel molecular marker related to cotton drought resistance and application thereof | 新疆农业大学 | 2022-12-06 | — | — | CN | disclosed |
| CN-114989276-A | Perilla salt tolerance-related protein PfWRKY33 and coding gene and application thereof | 湖南文理学院 | 2022-09-02 | — | — | CN | disclosed |
| CN-105585621-B | Soybean protein GmAIRP1 and its encoding gene and application | 哈尔滨师范大学 | 2019-03-12 | — | — | CN | disclosed |
| CN-105585620-B | Soybean protein GmAIRP1 and its encoding gene are cultivating the application in resistance plant | 哈尔滨师范大学 | 2019-02-01 | — | — | CN | disclosed |
| US-20180325103-A1 | AGRICULTURAL COMPOSITIONS FOR IMPROVED CROP PRODUCTIVITY AND ENHANCED PHENOTYPES | SPOGEN BIOTECH INC. (US) | 2018-11-15 | — | — | US | disclosed |
| US-20180066018-A1 | CONFORMATIONALLY STABLE ANALOGS OF THE RESPONSE SELECTIVE C5A AGONIST EP67 | THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA | 2018-03-08 | — | — | US | disclosed |
| CN-105713883-A | L-proline-4-hydroxylase and applications thereof | 中国科学院天津工业生物技术研究所 | 2016-06-29 | — | — | CN | disclosed |
| US-8586830-B2 | Ioslated TT1 polynucleotide, encoded proteins and vectors for increasing tolerance of plants and microbes to abiotic stresses and the use thereof | SICHUAN BIODESIGN GENE ENGINEERING CO., LTD. (CN) | 2013-11-19 | — | — | US | disclosed |
| US-20110258740-A1 | GENES, PROTEINS AND VECTORS FOR INCREASING TOLERANCE OF PLANTS AND MICROBES TO ABIOTIC STRESSES AND THE USE THEREOF | SICHUAN BIODESIGN GENE ENGINEERING CO., LTD. (CN) | 2011-10-20 | — | — | US | disclosed |
| CN-102112613-A | Genes, proteins and vectors for increaseing tolerance of plants and microbes to abiotic stresses and use thereof | SICHUAN BIODESIGN GENE ENGINEE | 2011-06-29 | — | — | CN | disclosed |
| EP-2319930-A1 | GENES, PROTEINS AND VECTORS FOR INCREASEING TOLERANCE OF PLANTS AND MICROBES TO ABIOTIC STRESSES AND THE USE THEREOF | Sichuan Biodesign Gene Engineering Co., Ltd. (CN) | 2011-05-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180066018-A1 | CONFORMATIONALLY STABLE ANALOGS OF THE RESPONSE SELECTIVE C5A AGONIST EP67 | C5AR1, C5AR2, C3AR1 | SCN4A 2460/4885ELANE 20/4885CTSC 429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.