Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KIF11 | P52732 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20239278 | 0.81 | PGR (0.47) | PGRMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL20239233 | 0.79 | ALDH1A1 (0.53) | MEN1KMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL4205144 | 0.77 | PGR (0.85) | PGRALDH1A1SMN1; SMN2KIF11RAB9A | |
| SCHEMBL18153300 | 0.74 | MEN1 (0.51) | MEN1KMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL18951960 | 0.74 | MEN1 (0.50) | MEN1KMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL18249752 | 0.72 | SMN1; SMN2 (0.51) | PGRMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL20239209 | 0.72 | PGR (0.49) | PGRMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL24173888 | 0.71 | KIF11 (0.47) | ALDH1A1SMN1; SMN2KIF11RAB9ALMNA | |
| SCHEMBL28431150 | 0.71 | MEN1 (0.47) | MEN1KMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL3116450 | 0.71 | PGR (0.73) | PGRMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3298001-B1 | DGAT2 INHIBITORS | LILLY CO ELI (US) | 2020-05-13 | — | — | EP | disclosed |
| EP-3298001-A1 | NOVEL DGAT2 INHIBITORS | Eli Lilly and Company (US) | 2018-03-28 | — | — | EP | disclosed |
| WO-2016187384-A1 | NOVEL DGAT2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2016-11-24 | — | — | WO | disclosed |