Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20239208 | 0.80 | DGAT2 (0.53) | PGRSMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL20239207 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL20239338 | 0.79 | SMN1; SMN2 (0.46) | PGRSMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL20472857 | 0.76 | PGR (0.52) | PGRSMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL20472862 | 0.75 | LOXL2 (0.58) | PGRSMN1; SMN2RAB9ANPC1HPGD | |
| SCHEMBL6160057 | 0.74 | PGR (0.49) | PGRSMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL4205144 | 0.73 | PGR (0.85) | PGRSMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL18249751 | 0.72 | PGR (0.54) | PGRSMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL20239168 | 0.72 | RAB9A (0.47) | SMN1; SMN2MEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL16742994 | 0.68 | GRIN1 (0.41) | PGRSMN1; SMN2MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | ELI LILY AND COMPANY (US) | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | DGAT2, DGAT1, LCAT | PGR 2121/4885SMN1; SMN2 4828/4885MEN1 4508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.