Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 14/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2824162 | 0.84 | ALDH1A1 (0.54) | P2RX7ALDH1A1ALOX15CRHBPHTT | |
| SCHEMBL4182412 | 0.82 | TDP1 (0.47) | P2RX7ALDH1A1L3MBTL1GAAMEN1 | |
| SCHEMBL29579998 | 0.80 | KDM4E (0.39) | P2RX7ALDH1A1ALOX15CRHBPHTT | |
| SCHEMBL10242696 | 0.79 | P2RX7 (0.49) | P2RX7ALDH1A1GAAMEN1KMT2A | |
| SCHEMBL2972393 | 0.79 | P2RX7 (0.53) | P2RX7ALDH1A1MEN1KMT2A | |
| SCHEMBL2172793 | 0.79 | P2RX7 (0.49) | P2RX7ALDH1A1L3MBTL1GAAMEN1 | |
| SCHEMBL352491 | 0.78 | P2RX7 (0.56) | P2RX7 | |
| SCHEMBL15012218 | 0.77 | LMNA (0.65) | ALDH1A1ALOX15CRHBPHTTCRHR2 | |
| Hydrochloric Acid SCHEMBL1372267 | 0.77 | P2RX7 (0.48) | P2RX7ALDH1A1L3MBTL1GAAMEN1 | |
| SCHEMBL14759859 | 0.77 | P2RX7 (0.48) | P2RX7ALDH1A1L3MBTL1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113651811-B | Isoxazole-containing pyridopyrimidone compound and preparation method and application thereof | 贵州大学 | 2022-06-07 | — | — | CN | disclosed |
| CN-113651811-A | Isoxazole-containing pyridopyrimidone compound and preparation method and application thereof | 贵州大学 | 2021-11-16 | — | — | CN | disclosed |
| CN-107709323-B | Hydroxyl purine compound and application thereof | 广东众生睿创生物科技有限公司 | 2020-11-20 | — | — | CN | disclosed |
| US-10278973-B2 | Hydroxyl purine compounds and use thereof | Guangdong Raynovent Biotech Co., Ltd. (CN) | 2019-05-07 | — | — | US | disclosed |
| US-10278973-B2 | Hydroxyl purine compounds and use thereof | Guangdong Raynovent Biotech Co., Ltd. (CN) | 2019-05-07 | — | — | US | disclosed |
| US-20180140607-A1 | HYDROXYL PURINE COMPOUNDS AND USE THEREOF | Guangdong Raynovent Biotech Co., Ltd. (CN) | 2018-05-24 | — | — | US | disclosed |
| US-20180140607-A1 | HYDROXYL PURINE COMPOUNDS AND USE THEREOF | Guangdong Raynovent Biotech Co., Ltd. (CN) | 2018-05-24 | — | — | US | disclosed |
| EP-3299371-A1 | HYDROXYL PURINE COMPOUNDS AND USE THEREOF | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2018-03-28 | — | — | EP | disclosed |
| EP-3299371-A1 | HYDROXYL PURINE COMPOUNDS AND USE THEREOF | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2018-03-28 | — | — | EP | disclosed |
| WO-2016184312-A1 | HYDROXYL PURINE COMPOUNDS AND USE THEREOF | 南京明德新药研发股份有限公司 | 2016-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180140607-A1 | HYDROXYL PURINE COMPOUNDS AND USE THEREOF | PNP, PDE7A, PDE2A | P2RX7 64/4885ALDH1A1 379/4885ALOX15 1143/4885 |
| US-10278973-B2 | Hydroxyl purine compounds and use thereof | PNP, PDE7A, PDE2A | P2RX7 64/4885ALDH1A1 379/4885ALOX15 1143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.