Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 11/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4170816 | 0.81 | GRM5 (0.53) | GRM5RAB9AALDH1A1NPC1KDM4E | |
| SCHEMBL4430798 | 0.76 | TSHR (0.51) | ALDH1A1KDM4ESMN1; SMN2HPGDMAOB | |
| SCHEMBL13998647 | 0.74 | HTR2A (0.40) | GRM5KMT2A | |
| SCHEMBL23667196 | 0.73 | MAP4K1 (0.39) | GRM5SMN1; SMN2MAOBLMNA | |
| SCHEMBL23667593 | 0.73 | MAP4K1 (0.39) | GRM5SMN1; SMN2MAOBLMNA | |
| SCHEMBL25832091 | 0.72 | GRM5 (0.39) | GRM5RAB9AALDH1A1NPC1KDM4E | |
| SCHEMBL21223432 | 0.72 | GRM5 (0.39) | GRM5ALDH1A1KDM4EHPGDMAOB | |
| SCHEMBL31069650 | 0.72 | GRM5 (0.39) | GRM5ALDH1A1KDM4EHPGDMAOB | |
| SCHEMBL9955316 | 0.72 | GRM5 (1.00) | GRM5RAB9AALDH1A1NPC1KDM4E | |
| SCHEMBL9835747 | 0.70 | GRM5 (0.51) | GRM5RAB9AALDH1A1NPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220125780-A1 | SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS | AURIGENE ONCOLOGY LIMITED (IN) | 2022-04-28 | — | — | US | disclosed |
| US-11229636-B2 | Substituted tetrahydroquinolinone compounds as ROR gamma modulators | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2022-01-25 | — | — | US | disclosed |
| EP-3845526-A1 | METHOD FOR THE PREPARATION OF TETRAHYDROQUINOLINONE COMPOUNDS HAVING ROR-GAMMA MODULATING ACTIVITY | Aurigene Discovery Technologies Limited (IN) | 2021-07-07 | — | — | EP | disclosed |
| US-20210113551-A9 | SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2021-04-22 | — | — | US | disclosed |
| EP-3294713-B1 | SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECH LTD (IN) | 2021-02-17 | — | — | EP | disclosed |
| US-20180200247-A1 | Substituted Tetrahydroquinolinone Compounds as ROR Gamma Modulators | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2018-07-19 | — | — | US | disclosed |
| US-20180200247-A1 | Substituted Tetrahydroquinolinone Compounds as ROR Gamma Modulators | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2018-07-19 | — | — | US | disclosed |
| WO-2016185342-A1 | SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2016-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11229636-B2 | Substituted tetrahydroquinolinone compounds as ROR gamma modulators | RORC, RORA, RORB | GRM5 475/4885RAB9A 736/4885ALDH1A1 235/4885 |
| US-20180200247-A1 | Substituted Tetrahydroquinolinone Compounds as ROR Gamma Modulators | RORC, RORA, RORB | GRM5 475/4885RAB9A 736/4885ALDH1A1 235/4885 |
| US-20210113551-A9 | SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS | RORC, RORA, RORB | GRM5 475/4885RAB9A 736/4885ALDH1A1 235/4885 |
| US-20220125780-A1 | SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS | RORC, RORA, RORB | GRM5 475/4885RAB9A 736/4885ALDH1A1 235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.