SCHEMBL1825807

SCHEMBL1825807

O=COc1cccc(Br)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.48
MAOB P27338 9/20 0.46
MAOA P21397 2/20 0.44
KMT2A Q03164 2/20 0.42
SOD1 P00441 1/20 0.41
CYP1A2 P05177 2/20 0.40
GAA P10253 1/20 0.40
MAPT P10636 1/20 0.40
RECQL P46063 1/20 0.40
KDM4E B2RXH2 2/20 0.39
LMNA P02545 1/20 0.39
CYP2C9 P11712 1/20 0.39
TSHR P16473 1/20 0.39
CYP2C19 P33261 1/20 0.39
MRGPRX4 Q96LA9 1/20 0.39
RAB9A P51151 1/20 0.39
SLC6A2 P23975 1/20 0.39
SLC6A4 P31645 1/20 0.39
SLC6A3 Q01959 1/20 0.39
MAPK1 P28482 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14877346 0.84 KMT2A (0.41) ALDH1A1MAOBMAOAKMT2AGAA
SCHEMBL20276711 0.79 ALDH1A1 (0.40) ALDH1A1MAOBMAOACYP1A2MAPT
SCHEMBL1547321 0.78 MAOB (0.46) ALDH1A1MAOBMAOAKMT2ASOD1
SCHEMBL5831450 0.78 MAOB (0.46) ALDH1A1MAOBMAOAKMT2ASOD1
SCHEMBL11511855 0.77 NCEH1 (0.47) ALDH1A1KMT2ACYP1A2MAPTKDM4E
SCHEMBL18875293 0.77 ERN1 (0.32) ALDH1A1SOD1
SCHEMBL3194381 0.77 SOD1 (0.34) ALDH1A1SOD1
SCHEMBL98036 0.74 ACHE (0.50) ALDH1A1MAOBKMT2ACYP1A2LMNA
SCHEMBL14227696 0.74 SLC6A2 (0.39) SLC6A2SLC6A4SLC6A3
SCHEMBL513410 0.74 ALDH1A1 (0.54) ALDH1A1MAOBMAOAKMT2AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115124528-B Pyrrolopyridine compound, and preparation method and medical application thereof 徐州医科大学 2023-10-27 CN disclosed
CN-115124528-A Pyrrolopyridine compound and preparation method and medical application thereof 徐州医科大学 2022-09-30 CN disclosed
US-20180219159-A1 ORGANIC MOLECULES HAVING TWO NON-CONJUGATED BRIDGES BETWEEN A DONOR AND AN ACCEPTOR FOR EFFECTIVE THERMALLY ACTIVATED DELAYED FLUORESCENCE FOR USE IN OPTOELECTRONIC DEVICES SICHUAN KNOWLEDGE EXPRESS INSTITUTE FOR INNOVATIVE TECHNOLOGIES CO., LTD (CN) 2018-08-02 US disclosed
CN-107835680-A The novel beta hydroxysteroid dehydrogenase of 1 type of selectivity 11 帝斯曼知识产权资产管理有限公司 2018-03-23 CN disclosed
US-20170190713-A1 FUSED QUADRACYCLIC COMPOUNDS, COMPOSITIONS AND USES THEREOF WUXI APPTEC (HONG KONG) CO., LIMITED (HK) 2017-07-06 US disclosed
US-20130078213-A1 THROMBOPOIETIN MIMETICS GLAXOSMITHKLINE LLC 2013-03-28 US disclosed
EP-2570418-A2 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2013-03-20 EP disclosed
EP-1555267-B1 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES OTSUKA PHARMA CO LTD (JP) 2013-01-16 EP disclosed
CN-101823989-B Polymer for resist, resist composition, pattern forming method and material compound for resist polymer MITSUBISHI RAYON CO 2012-05-09 CN disclosed
US-8163753-B2 2-(4-(4-(4-chlorophenyl)oxazol-2-yl)phenoxymethyl)-2-methyl-6-nitro-2,3-dihydroimidazo[2,1-b]oxazole; bactericide; excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2012-04-24 US disclosed
EP-0153145-B1 PHOTORECEPTOR KONICA CORPORATION (JP) 1988-06-08 EP disclosed
US-4737430-A Electrophotographic photoreceptor with azo-containing photosensitive member KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1988-04-12 US disclosed
US-4647520-A Electrophotographic photoreceptor containing an azo compound KONOSHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1987-03-03 US disclosed
EP-0188055-A2 Photoreceptor KONICA CORPORATION (JP) 1986-07-23 EP disclosed
US-4579800-A HIGH STABILITY WITH RESPECT TO LIGHT AND HEAT KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1986-04-01 US disclosed
US-4576886-A ELECTROGRAPHY KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1986-03-18 US disclosed
EP-0156481-A2 Photoreceptor KONICA CORPORATION (JP) 1985-10-02 EP disclosed
EP-0153145-A2 Photoreceptor KONICA CORPORATION (JP) 1985-08-28 EP disclosed
EP-0145348-A2 Photoreceptor KONICA CORPORATION (JP) 1985-06-19 EP disclosed
US-4259350-A PROTECTING DEGRADABLE ORGANIC MATERIAL FROM FUNGAL OR INSECT ATTACK SANKYO COMPANY LIMITED (JP) 1981-03-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130078213-A1 THROMBOPOIETIN MIMETICS MPL, THPO, TEK ALDH1A1 1012/4885MAOB 524/4885MAOA 1867/4885
US-20170190713-A1 FUSED QUADRACYCLIC COMPOUNDS, COMPOSITIONS AND USES THEREOF MKNK2, CYP2J2, PTGS2 ALDH1A1 4091/4885MAOB 2417/4885MAOA 2478/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.