Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ELANE | P08246 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30774201 | 1.00 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1KDM4EELANEPARP1 | |
| SCHEMBL28676590 | 0.81 | ENPP1 (0.48) | ALDH1A1L3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL30774158 | 0.81 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL30950214 | 0.81 | ENPP1 (0.48) | ALDH1A1L3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL9794609 | 0.81 | KDM4E (0.39) | ALDH1A1L3MBTL1KDM4EELANEPARP1 | |
| SCHEMBL24373483 | 0.81 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL29479071 | 0.80 | KDM4E (0.51) | ALDH1A1KDM4EMEN1KMT2ATNKS | |
| SCHEMBL24373525 | 0.80 | KDM4E (0.51) | ALDH1A1KDM4EMEN1KMT2ATNKS | |
| SCHEMBL10810254 | 0.79 | ELANE (0.44) | ALDH1A1L3MBTL1KDM4EELANEPARP1 | |
| SCHEMBL25805536 | 0.78 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3302060-B1 | PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF -GLUCURONIDASE | UNIV KAOHSIUNG MEDICAL (TW) | 2020-02-12 | — | — | EP | claimed |
| US-20180214426-A1 | PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF BETA-GLUCURONIDASE | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2018-08-02 | — | — | US | claimed |
| EP-3302060-A1 | PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF -GLUCURONIDASE | Kaohsiung Medical University (TW) | 2018-04-11 | — | — | EP | claimed |
| CN-107708419-A | Pyrazolo [4,3-c ] quinoline derivatives having inhibitory activity on bacterial glucuronidase | 高雄医学大学 | 2018-02-16 | — | — | CN | claimed |
| WO-2016191576-A1 | PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF β-GLUCURONIDASE | DCB-USA LLC (US) | 2016-12-01 | — | — | WO | claimed |
| US-20240059703-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | AMGEN INC. | 2024-02-22 | — | — | US | disclosed |
| WO-2022083569-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2022-04-28 | — | — | WO | disclosed |
| CN-111514144-B | Pyrazolo [4,3-c ] quinoline derivatives having inhibitory activity on bacterial glucuronidase | 高雄医学大学 | 2021-10-26 | — | — | CN | disclosed |
| EP-3662751-B1 | PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF B-GLUCURONIDASE | UNIV KAOHSIUNG MEDICAL (TW) | 2021-10-13 | — | — | EP | disclosed |
| US-11135206-B2 | Pyrazolo[4,3-c]quinoline derivatives for inhibition of β-glucuronidase | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2021-10-05 | — | — | US | disclosed |
| CN-107708419-B | Pyrazolo [4,3-c ] quinoline derivatives having inhibitory activity on bacterial glucuronidase | 高雄医学大学 | 2021-08-27 | — | — | CN | disclosed |
| US-11052072-B2 | Pyrazolo[4,3-C] quinoline derivatives for inhibition of β-glucuronidase | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2021-07-06 | — | — | US | disclosed |
| CN-111514144-A | Pyrazolo [4,3-c ] quinoline derivatives having inhibitory activity on bacterial glucuronidase | 高雄医学大学 | 2020-08-11 | — | — | CN | disclosed |
| EP-3662751-A1 | PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF B-GLUCURONIDASE | Kaohsiung Medical University (TW) | 2020-06-10 | — | — | EP | disclosed |
| US-20200113878-A1 | PYRAZOLO[4,3-C]Quinoline Derivatives For Inhibition Of Beta-Glucuronidase | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2020-04-16 | — | — | US | disclosed |
| EP-3302060-B1 | PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF -GLUCURONIDASE | UNIV KAOHSIUNG MEDICAL (TW) | 2020-02-12 | — | — | EP | disclosed |
| US-20180214426-A1 | PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF BETA-GLUCURONIDASE | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2018-08-02 | — | — | US | disclosed |
| EP-3302060-A1 | PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF -GLUCURONIDASE | Kaohsiung Medical University (TW) | 2018-04-11 | — | — | EP | disclosed |
| CN-107708419-A | Pyrazolo [4,3-c ] quinoline derivatives having inhibitory activity on bacterial glucuronidase | 高雄医学大学 | 2018-02-16 | — | — | CN | disclosed |
| WO-2016191576-A1 | PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF β-GLUCURONIDASE | DCB-USA LLC (US) | 2016-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180214426-A1 | PYRAZOLO[4,3-C]QUINOLINE DERIVATIVES FOR INHIBITION OF BETA-GLUCURONIDASE | UGT1A3, UGT1A1, GUSB | ALDH1A1 43/4885L3MBTL1 4628/4885KDM4E 3240/4885 |
| US-20240059703-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | KRAS, HRAS, APC | ALDH1A1 1221/4885L3MBTL1 4517/4885KDM4E 4694/4885 |
| US-20200113878-A1 | PYRAZOLO[4,3-C]Quinoline Derivatives For Inhibition Of Beta-Glucuronidase | UGT1A3, UGT1A1, GUSB | ALDH1A1 43/4885L3MBTL1 4628/4885KDM4E 3240/4885 |
| US-11052072-B2 | Pyrazolo[4,3-C] quinoline derivatives for inhibition of β-glucuronidase | UGT1A3, UGT1A1, DPP3 | ALDH1A1 42/4885L3MBTL1 4637/4885KDM4E 3159/4885 |
| US-11135206-B2 | Pyrazolo[4,3-c]quinoline derivatives for inhibition of β-glucuronidase | UGT1A3, UGT1A1, DPP3 | ALDH1A1 42/4885L3MBTL1 4637/4885KDM4E 3159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.