Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | GAPDH | P04406 | 2/20 | 0.47 |
| ▸ | HRAS | P01112 | 1/20 | 0.45 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.43 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1826966 | 1.00 | POLB (0.60) | POLBMEN1USP2KMT2AALDH1A1 | |
| SCHEMBL10244723 | 0.93 | ALDH1A1 (0.52) | POLBMEN1USP2KMT2AALDH1A1 | |
| SCHEMBL14570583 | 0.93 | ALDH1A1 (0.52) | POLBMEN1USP2KMT2AALDH1A1 | |
| SCHEMBL17612287 | 0.92 | POLB (0.54) | POLBMEN1USP2KMT2AALDH1A1 | |
| SCHEMBL11442315 | 0.85 | USP2 (0.62) | POLBMEN1USP2KMT2AALDH1A1 | |
| SCHEMBL10260643 | 0.81 | MEN1 (0.58) | POLBMEN1USP2KMT2AALDH1A1 | |
| SCHEMBL15702572 | 0.81 | MEN1 (0.58) | POLBMEN1USP2KMT2AALDH1A1 | |
| SCHEMBL7706306 | 0.81 | POLB (0.58) | POLBMEN1USP2KMT2AALDH1A1 | |
| SCHEMBL10706978 | 0.81 | MEN1 (0.56) | POLBMEN1USP2KMT2AALDH1A1 | |
| SCHEMBL7712704 | 0.81 | MEN1 (0.58) | POLBMEN1USP2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2319853-B1 | Process for the production of 2'-branched nucleosides | IDENIX PHARMACEUTICALS INC (US) | 2014-03-12 | — | — | EP | disclosed |
| EP-2319853-A1 | Process for the production of 2'-branched nucleosides | Idenix (Cayman) Limited (KY) | 2011-05-11 | — | — | EP | disclosed |
| US-7598373-B2 | Process for the production of 2-C-methyl-D-ribonolactone | IDENIX PHARMACEUTICALS, INC. (US) | 2009-10-06 | — | — | US | disclosed |
| US-7582748-B2 | efficient synthetic route to an optionally protected 1-halo-2-deoxyribose; formation of an alkyl acetal, such as a methyl acetal, of a furanose, such as 2-deoxyribose, optionally protecting the remaining hydroxyl groups of the furanose, reacting the acetal with an acyl halide that forms the acid halide | MICROBIOLOGICA QUIMICA E FARMACEUTICAL LTD. (BR) | 2009-09-01 | — | — | US | disclosed |
| EP-1585529-A4 | PROCESS FOR THE PRODUCTION OF 2'-BRANCHED NUCLEOSIDES | IDENIX CAYMAN LTD (KY) | 2008-05-28 | — | — | EP | disclosed |
| EP-1575971-A4 | PROCESS FOR THE PRODUCTION OF 3 -NUCLEOSIDE PRODRUGS | IDENIX CAYMAN LTD (KY) | 2008-03-05 | — | — | EP | disclosed |
| EP-1745573-A2 | METHODS OF MANUFACTURE OF 2 -DEOXY-&bgr;-L-NUCLEOSIDES | Microbiologica Quimica E Farmaceutica Ltd. (BR) | 2007-01-24 | — | — | EP | disclosed |
| EP-1585529-A2 | PROCESS FOR THE PRODUCTION OF 2'-BRANCHED NUCLEOSIDES | Idenix (Cayman) Limited (KY) | 2005-10-19 | — | — | EP | disclosed |
| EP-1575971-A1 | PROCESS FOR THE PRODUCTION OF 3 -NUCLEOSIDE PRODRUGS | Idenix (Cayman) Limited (KY) | 2005-09-21 | — | — | EP | disclosed |
| US-20050020825-A1 | Process for the production of 2'-branched nucleosides | IDENIX PHARMACEUTICALS LLC | 2005-01-27 | — | — | US | disclosed |
| US-20040266996-A1 | Methods of manufacture of 2'-deoxy-beta-L-nucleosides | MICROBIOLOGICA QUIMICA E FARMACEUTICA LTD. (BR) | 2004-12-30 | — | — | US | disclosed |
| WO-2004084453-A2 | METHODS OF MANUFACTURE OF 2'-DEOXY-β-L-NUCLEOSIDES | MICROBIOLOGICA QUIMICA E FARMACEUTICA LTD. (BR) | 2004-09-30 | — | — | WO | disclosed |
| US-20040181051-A1 | Process for the production of 3'-nucleoside prodrugs | STORER RICHARD (GB) | 2004-09-16 | — | — | US | disclosed |
| WO-2004058792-A1 | PROCESS FOR THE PRODUCTION OF 3'-NUCLEOSIDE PRODRUGS | IDENIX (CAYMAN) LIMITED (KY) | 2004-07-15 | — | — | WO | disclosed |
| WO-2004052899-A2 | PROCESS FOR THE PRODUCTION OF 2'-BRANCHED NUCLEOSIDES | IDENIX (CAYMAN) LIMITED (KY) | 2004-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266996-A1 | Methods of manufacture of 2'-deoxy-beta-L-nucleosides | DUT, DAO, DCTD | POLB 216/4885MEN1 3439/4885USP2 2267/4885 |
| US-20040181051-A1 | Process for the production of 3'-nucleoside prodrugs | PNP, GART, UMPS | POLB 853/4885MEN1 4748/4885USP2 4137/4885 |
| US-20050020825-A1 | Process for the production of 2'-branched nucleosides | RNGTT, MTAP, NSUN2 | POLB 68/4885MEN1 3011/4885USP2 3883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.