Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 3/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1166469 | 0.75 | MAOA (0.55) | MAOBMAOAPOLBCA12CA9 | |
| SCHEMBL4075158 | 0.75 | MAPT (0.47) | MAOBMAOAPOLBCA12CA9 | |
| SCHEMBL28399285 | 0.73 | MAOB (0.56) | MAOBMAOAPOLBCA12CA9 | |
| SCHEMBL182523 | 0.73 | PDE3B (0.58) | PDE3BPDE3AMAOBMAOACA12 | |
| SCHEMBL28918547 | 0.72 | KDM4E (0.54) | MAOBMAOAPOLBCA12CA9 | |
| SCHEMBL18936062 | 0.71 | MAOB (0.55) | MAOBMAOAPOLBCA12CA9 | |
| SCHEMBL17199261 | 0.71 | MAOB (0.55) | MAOBMAOAPOLBCA12CA9 | |
| SCHEMBL5177829 | 0.71 | CA12 (0.57) | MAOBMAOAPOLBCA12CA9 | |
| SCHEMBL12778676 | 0.71 | MAOB (0.55) | MAOBMAOAPOLBCA12CA9 | |
| SCHEMBL266607 | 0.71 | CA12 (0.57) | MAOBMAOAPOLBCA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108727367-B | Benzoxazinone compound containing pyridopyrimidinedione, preparation method and application thereof, and herbicide composition | 山东先达农化股份有限公司 | 2021-01-05 | — | — | CN | disclosed |
| US-9975862-B2 | Arylpiperazine derivatives and methods of utilizing same | REVIVA PHARMACEUTICALS, INC. (US) | 2018-05-22 | — | — | US | disclosed |
| US-20170327477-A1 | ARYLPIPERAZINE DERIVATIVES AND METHODS OF UTILIZING SAME | REVIVA PHARMACEUTICALS INC (US) | 2017-11-16 | — | — | US | disclosed |
| US-9604944-B2 | Arylpiperazine derivatives and methods of utilizing same | REVIVA PHARMACEUTICALS, INC. (US) | 2017-03-28 | — | — | US | disclosed |
| EP-2400968-B1 | COMPOSITIONS, SYNTHESIS, AND METHODS OF UTILIZING ARYLPIPERAZINE DERIVATIVES | REVIVA PHARMACEUTICALS INC (US) | 2016-09-28 | — | — | EP | disclosed |
| US-20160229821-A1 | ARYLPIPERAZINE DERIVATIVES AND METHODS OF UTILIZING SAME | REVIVA PHARMACEUTICALS INC (US) | 2016-08-11 | — | — | US | disclosed |
| US-9255076-B2 | Arylpiperazine derivatives and methods of utilizing same | REVIVA PHARMACEUTICALS, INC. (US) | 2016-02-09 | — | — | US | disclosed |
| US-20150166493-A1 | ARYLPIPERAZINE DERIVATIVES AND METHODS OF UTILIZING SAME | REVIVA PHARMACEUTICALS INC (US) | 2015-06-18 | — | — | US | disclosed |
| US-8980883-B2 | Arylpiperazine derivatives and methods of utilizing same | REVIVA PHARMACEUTICALS, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| US-20150005298-A1 | ARYLPIPERAZINE DERIVATIVES AND METHODS OF UTILIZING SAME | REVIVA PHARMACEUTICALS INC (US) | 2015-01-01 | — | — | US | disclosed |
| US-20120220574-A1 | METHODS OF UTILIZING ARYLPIPERAZINE DERIVATIVES | BHAT LAXMINARAYAN (US) | 2012-08-30 | — | — | US | disclosed |
| US-20120220579-A1 | METHODS OF UTILIZING ARYLPIPERAZINE DERIVATIVES | BHAT LAXMINARAYAN (US) | 2012-08-30 | — | — | US | disclosed |
| US-8188076-B2 | Compositions, synthesis, and methods of utilizing arylpiperazine derivatives | REVIVA PHARMACEUTICALS, INC. (US) | 2012-05-29 | — | — | US | disclosed |
| EP-2400968-A1 | COMPOSITIONS, SYNTHESIS, AND METHODS OF UTILIZING ARYLPIPERAZINE DERIVATIVES | Reviva Pharmaceuticals, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010099502-A1 | COMPOSITIONS, SYNTHESIS, AND METHODS OF UTILIZING ARYLPIPERAZINE DERIVATIVES | REVIVA PHARMACEUTICALS, INC. (US) | 2010-09-02 | — | — | WO | disclosed |
| US-20100216783-A1 | COMPOSITIONS, SYNTHESIS, AND METHODS OF UTILIZING ARYLPIPERAZINE DERIVATIVES | REVIVA PHARMACEUTICALS, INC. | 2010-08-26 | — | — | US | disclosed |
| US-7354915-B2 | 6-amino-1,4-dihydro-benzo[d][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators | WYETH (US) | 2008-04-08 | — | — | US | disclosed |
| US-20070225281-A1 | 6-Amino-1,4-dihydro-benzo[d][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators | WYETH (US) | 2007-09-27 | — | — | US | disclosed |
| US-7247625-B2 | 6-amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators | WYETH (US) | 2007-07-24 | — | — | US | disclosed |
| US-20050085470-A1 | 6-Amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators | WYETH | 2005-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170327477-A1 | ARYLPIPERAZINE DERIVATIVES AND METHODS OF UTILIZING SAME | GRIK5, HTR5A, GRIK2 | PDE3B 1029/4885PDE3A 1122/4885MAOB 86/4885 |
| US-20160229821-A1 | ARYLPIPERAZINE DERIVATIVES AND METHODS OF UTILIZING SAME | GRIK5, HTR5A, GRIK2 | PDE3B 1029/4885PDE3A 1122/4885MAOB 86/4885 |
| US-20150005298-A1 | ARYLPIPERAZINE DERIVATIVES AND METHODS OF UTILIZING SAME | GRIK5, HTR5A, HTR2A | PDE3B 1287/4885PDE3A 1321/4885MAOB 110/4885 |
| US-20120220579-A1 | METHODS OF UTILIZING ARYLPIPERAZINE DERIVATIVES | HTR5A, GRIK5, HTR2A | PDE3B 1244/4885PDE3A 1286/4885MAOB 156/4885 |
| US-20120220574-A1 | METHODS OF UTILIZING ARYLPIPERAZINE DERIVATIVES | HTR5A, GRIK5, HTR2A | PDE3B 1244/4885PDE3A 1286/4885MAOB 156/4885 |
| US-20050085470-A1 | 6-Amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators | PGR, FSHR, GPR6 | PDE3B 3706/4885PDE3A 3745/4885MAOB 2225/4885 |
| US-20070225281-A1 | 6-Amino-1,4-dihydro-benzo[d][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators | PGR, FSHR, GPR6 | PDE3B 3706/4885PDE3A 3745/4885MAOB 2225/4885 |
| US-20150166493-A1 | ARYLPIPERAZINE DERIVATIVES AND METHODS OF UTILIZING SAME | GRIK5, HTR5A, HTR2A | PDE3B 1287/4885PDE3A 1321/4885MAOB 110/4885 |
| US-20100216783-A1 | COMPOSITIONS, SYNTHESIS, AND METHODS OF UTILIZING ARYLPIPERAZINE DERIVATIVES | GRIK5, HTR5A, KYNU | PDE3B 1321/4885PDE3A 1396/4885MAOB 65/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.