SCHEMBL1828047

SCHEMBL1828047

COC(=O)/C(C)=C/[C@H]1COC(C)(C)O1

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CA2 P00918 2/20 0.34
L3MBTL1 Q9Y468 1/20 0.32
HCRTR1 O43613 3/20 0.31
HCRTR2 O43614 3/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3683013 1.00 CA2 (0.34) CA2L3MBTL1HCRTR1HCRTR2
SCHEMBL4421277 0.87 RECQL (0.34) CA2L3MBTL1HCRTR1HCRTR2
SCHEMBL13568693 0.87 RECQL (0.34) CA2L3MBTL1HCRTR1HCRTR2
SCHEMBL6065572 0.84 L3MBTL1 (0.31) L3MBTL1HCRTR1HCRTR2
SCHEMBL9695840 0.84 L3MBTL1 (0.33) L3MBTL1HCRTR1HCRTR2
SCHEMBL3218626 0.83 LMNA (0.36) CA2
SCHEMBL3218630 0.83 LMNA (0.36) CA2
SCHEMBL768274 0.83 LMNA (0.36) CA2
SCHEMBL475955 0.83 LMNA (0.36) CA2
SCHEMBL21049862 0.81

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2319853-B1 Process for the production of 2'-branched nucleosides IDENIX PHARMACEUTICALS INC (US) 2014-03-12 EP disclosed
EP-1976382-B1 PROCESS FOR PREPARING A SYNTHETIC INTERMEDIATE FOR PREPARATION OF BRANCHED NUCLEOSIDES IDENIX PHARMACEUTICALS INC (US) 2013-04-24 EP disclosed
EP-2319853-A1 Process for the production of 2'-branched nucleosides Idenix (Cayman) Limited (KY) 2011-05-11 EP disclosed
US-7598373-B2 Process for the production of 2-C-methyl-D-ribonolactone IDENIX PHARMACEUTICALS, INC. (US) 2009-10-06 US disclosed
EP-1976382-A2 PROCESS FOR PREPARING A SYNTHETIC INTERMEDIATE FOR PREPARATION OF BRANCHED NUCLEOSIDES IDENIX Pharmaceuticals, Inc. (US) 2008-10-08 EP disclosed
EP-1585529-A4 PROCESS FOR THE PRODUCTION OF 2'-BRANCHED NUCLEOSIDES IDENIX CAYMAN LTD (KY) 2008-05-28 EP disclosed
WO-2007075876-A2 PROCESS FOR PREPARING A SYNTHETIC INTERMEDIATE FOR PREPARATION OF BRANCHED NUCLEOSIDES IDENIX PHARMACEUTICALS, INC. (US) 2007-07-05 WO disclosed
CN-1744903-A Process for the preparation of 2' -branched nucleosides IDENIX CAYMAN LTD (KY) 2006-03-08 CN disclosed
EP-1585529-A2 PROCESS FOR THE PRODUCTION OF 2'-BRANCHED NUCLEOSIDES Idenix (Cayman) Limited (KY) 2005-10-19 EP disclosed
US-20050020825-A1 Process for the production of 2'-branched nucleosides IDENIX PHARMACEUTICALS LLC 2005-01-27 US disclosed
WO-2004052899-A2 PROCESS FOR THE PRODUCTION OF 2'-BRANCHED NUCLEOSIDES IDENIX (CAYMAN) LIMITED (KY) 2004-06-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050020825-A1 Process for the production of 2'-branched nucleosides RNGTT, MTAP, NSUN2 CA2 4424/4885L3MBTL1 472/4885HCRTR1 4675/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.