Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.41 |
| ▸ | RAB9A | P51151 | 11/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | METTL3 | Q86U44 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18283257 | 0.72 | RAB9A (0.47) | NPC1RAB9ASMN1; SMN2KDM4ETP53 | |
| SCHEMBL4434358 | 0.71 | GABRA1 (0.32) | CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4436859 | 0.68 | NR1I2 (0.33) | — | |
| SCHEMBL4435508 | 0.68 | PNMT (0.31) | — | |
| SCHEMBL8174291 | 0.67 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2KDM4ETP53 | |
| SCHEMBL5982381 | 0.67 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2KDM4ETP53 | |
| Hydrochloric Acid SCHEMBL22499245 | 0.66 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2KDM4ETP53 | |
| SCHEMBL13633339 | 0.66 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2KDM4ETP53 | |
| SCHEMBL358067 | 0.66 | RAB9A (0.42) | NPC1RAB9ASMN1; SMN2KDM4ETP53 | |
| SCHEMBL23530863 | 0.64 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3644996-A1 | METHODS FOR TREATING HUNTINGTON'S DISEASE | PTC Therapeutics, Inc. (US) | 2020-05-06 | — | — | EP | disclosed |
| EP-3645121-A1 | METHODS FOR TREATING HUNTINGTON'S DISEASE | PTC Therapeutics, Inc. (US) | 2020-05-06 | — | — | EP | disclosed |
| WO-2019005980-A1 | METHODS FOR TREATING HUNTINGTON'S DISEASE | PTC THERAPEUTICS, INC. (US) | 2019-01-03 | — | — | WO | disclosed |
| WO-2019005993-A1 | METHODS FOR TREATING HUNTINGTON'S DISEASE | PTC THERAPEUTICS, INC. (US) | 2019-01-03 | — | — | WO | disclosed |
| EP-3310169-A1 | METHODS FOR MODULATING RNA SPLICING | PTC Therapeutics, Inc. (US) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016196386-A1 | METHODS FOR MODULATING RNA SPLICING | PTC THERAPEUTICS, INC. (US) | 2016-12-08 | — | — | WO | disclosed |