Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434358 | 0.82 | GABRA1 (0.32) | — | |
| SCHEMBL4435508 | 0.82 | PNMT (0.31) | — | |
| SCHEMBL15068507 | 0.72 | — | — | |
| SCHEMBL2315461 | 0.70 | NUDT1 (0.41) | NR1I2HSD11B1APOBEC3G | |
| SCHEMBL18283243 | 0.68 | NPC1 (0.41) | — | |
| SCHEMBL4441329 | 0.68 | NR1I2 (0.33) | NR1I2HSD11B1 | |
| SCHEMBL2315975 | 0.67 | NPC1 (0.38) | — | |
| SCHEMBL25515799 | 0.66 | APOBEC3G (0.38) | APOBEC3G | |
| SCHEMBL2313781 | 0.64 | NPC1 (0.35) | NR1I2HSD11B1 | |
| SCHEMBL2315424 | 0.64 | ALDH1A3 (0.67) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618981-B2 | to treat cellular proliferative diseases, hyperplasias, solid tumor, cardiac hypertrophy, immune disorders and inflammation; modulators of one or more mitotic kinesins; N-(2-(2-dimethylamino-acetylamino)-1-{4-[8-(1-hydroxy-ethyl)-imidazo[1,2-a]pyridin-2-yl]-benzyl}-ethyl)-3-chloro-4-isopropoxy-benzamide | CYTOKINETICS, INC. (US) | 2009-11-17 | — | — | US | claimed |