SCHEMBL18286459

SCHEMBL18286459

CCCC(Oc1ccc(F)c(C(C)=O)c1F)c1nc(-c2ccc(Cl)cc2)c(Br)o1

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TARBP2 Q15633 1/20 0.32
CTSA P10619 1/20 0.31
PPARG P37231 2/20 0.30
PPARA Q07869 2/20 0.30
FPR2 P25090 1/20 0.30
SCN9A Q15858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18286457 0.93 TARBP2 (0.33) TARBP2CTSA
SCHEMBL13732602 0.92 SCN9A (0.35) TARBP2CTSAPPARGPPARAFPR2
SCHEMBL18286446 0.88 FFAR4 (0.34) TARBP2CTSAPPARGPPARA
SCHEMBL18286445 0.86 TARBP2 (0.30) TARBP2
SCHEMBL18286424 0.86 SMN1; SMN2 (0.34) TARBP2CTSAFPR2SCN9A
SCHEMBL13733148 0.84 SCN9A (0.34) TARBP2CTSAFPR2SCN9A
SCHEMBL19210474 0.82 RXRA (0.34) CTSAFPR2SCN9A
SCHEMBL18286426 0.82 FFAR4 (0.35) TARBP2CTSAPPARGPPARAFPR2
SCHEMBL13733585 0.81 SCN9A (0.35) CTSAFPR2SCN9A
SCHEMBL13732764 0.81 FPR2 (0.33) TARBP2CTSAFPR2SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9511073-B2 Aromatic amides and uses thereof TAXIS PHARMACEUTICALS, INC. (US) 2016-12-06 US disclosed