Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 13/20 | 0.47 |
| ▸ | IKBKB | O14920 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12295752 | 0.73 | CFTR (0.57) | CFTRIKBKB | |
| SCHEMBL30951245 | 0.69 | SMN1; SMN2 (0.39) | CFTRIKBKBSMN1; SMN2KMT2AMAP4K1 | |
| SCHEMBL18293452 | 0.69 | CFTR (0.42) | CFTRIKBKBSMN1; SMN2MAP4K1 | |
| SCHEMBL14789606 | 0.69 | CFTR (0.60) | CFTR | |
| SCHEMBL2153631 | 0.68 | ALDH1A1 (0.43) | SMN1; SMN2KMT2A | |
| SCHEMBL28931444 | 0.67 | CFTR (0.33) | CFTRKMT2A | |
| SCHEMBL11978271 | 0.64 | CFTR (0.44) | CFTRIKBKBSMN1; SMN2 | |
| SCHEMBL30259615 | 0.64 | CFTR (0.44) | CFTRIKBKBSMN1; SMN2 | |
| SCHEMBL21199669 | 0.64 | POLB (0.43) | CFTRIKBKBMAP4K1 | |
| SCHEMBL28719025 | 0.64 | IDO1 (0.46) | CFTRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160355480-A1 | SUBSTITUTED PYRIDINES AND METHOD OF USE | ABBVIE OVERSEAS S.Á.R.L. (LU) | 2016-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160355480-A1 | SUBSTITUTED PYRIDINES AND METHOD OF USE | CFTR, P2RY1, XDH | CFTR 1/4885IKBKB 3376/4885SMN1; SMN2 3575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.