Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.72 |
| ▸ | ACP1 | P24666 | 8/20 | 0.67 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.66 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.66 |
| ▸ | RELA | Q04206 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | NCS1 | P62166 | 1/20 | 0.63 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25938107 | 0.82 | CSNK1D (0.69) | ALDH1A1MAPK1ACP1CSNK1DSMN1; SMN2 | |
| SCHEMBL29282910 | 0.82 | DYRK1A (0.69) | ALDH1A1MAPK1ACP1CSNK1DSMN1; SMN2 | |
| SCHEMBL4858014 | 0.82 | CSNK1D (0.69) | ALDH1A1MAPK1ACP1CSNK1DSMN1; SMN2 | |
| SCHEMBL6206186 | 0.82 | RAB9A (0.72) | ALDH1A1MAPK1ACP1CSNK1DSMN1; SMN2 | |
| SCHEMBL29485044 | 0.82 | DYRK1A (0.69) | ALDH1A1MAPK1ACP1CSNK1DSMN1; SMN2 | |
| SCHEMBL29485043 | 0.82 | DYRK1A (0.69) | ALDH1A1MAPK1ACP1CSNK1DSMN1; SMN2 | |
| Ethylene SCHEMBL8167289 | 0.82 | CSNK1D (0.69) | ALDH1A1MAPK1ACP1CSNK1DSMN1; SMN2 | |
| SCHEMBL7933388 | 0.82 | HDAC3 (0.71) | ALDH1A1MAPK1ACP1CSNK1DSMN1; SMN2 | |
| SCHEMBL5313704 | 0.82 | CSNK1D (0.69) | ALDH1A1MAPK1ACP1CSNK1DSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL25333657 | 0.81 | CSNK1D (0.68) | ALDH1A1MAPK1ACP1CSNK1DSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180170861-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES AND USED THEREOF | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2018-06-21 | — | — | US | disclosed |
| US-20180170862-A1 | PROTEIN TYROSINE PHOSPHATASES OR SHP2 INHIBITORS AND USES THEREOF | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2018-06-21 | — | — | US | disclosed |
| WO-2016196591-A1 | PROTEIN TYROSINE PHOSPHATASES OR SHP2 INHIBITORS AND USES THEREOF | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2016-12-08 | — | — | WO | disclosed |
| WO-2016196569-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES AND USES THEREOF | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2016-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180170861-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES AND USED THEREOF | PTPA, EPM2A, PTPRA | ALDH1A1 1680/4885MAPK1 1259/4885ACP1 66/4885 |
| US-20180170862-A1 | PROTEIN TYROSINE PHOSPHATASES OR SHP2 INHIBITORS AND USES THEREOF | PTPA, PTPRA, PTPRCAP | ALDH1A1 2439/4885MAPK1 852/4885ACP1 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.